Takeuchi M, Nagai S, Izumi T
Second Department of Internal Medicine, Kyoto University, Japan.
Chest. 1988 Oct;94(4):688-93. doi: 10.1378/chest.94.4.688.
We investigated the effect of smoking on natural killer (NK) cell activity and distribution in bronchoalveolar lavage fluid (BALF) and blood. Initially, BALF NK cell activity was lower than the blood NK cell activity both in non-smokers (NS) and smokers (S). Following 24 hour culture, NK cell activity markedly increased in NS but not in S. Percentage distribution of Leu-7+ cells and Leu-11+ cells in BALF was similar in NS and S. But the BALF NK cell activity was significantly augmented by IL-2 or OK-432 (a streptococcal preparation) in NS. It appears that smoking reduces NK cell activity in BALF. It is conceivable that the low NK cell activity in BALF in S might contribute to increased incidence of infection and malignancy in smokers.
我们研究了吸烟对支气管肺泡灌洗液（BALF）和血液中自然杀伤（NK）细胞活性及分布的影响。起初，无论是不吸烟者（NS）还是吸烟者（S），BALF中NK细胞活性均低于血液中NK细胞活性。经过24小时培养后，NS组NK细胞活性显著增加，而S组则未增加。NS组和S组BALF中Leu-7+细胞和Leu-11+细胞的百分比分布相似。但在NS组中，IL-2或OK-432（一种链球菌制剂）可显著增强BALF中NK细胞活性。似乎吸烟会降低BALF中NK细胞活性。可以想象，S组BALF中NK细胞活性较低可能导致吸烟者感染和恶性肿瘤发病率增加。
