关于源自生活方式和衰老的人类自然杀伤细胞改变的癌症和病毒感染免疫监视

Deng Xuewen, Terunuma Hiroshi, Nieda Mie

Biotherapy Institute of Japan, Inc., 2-4-8 Edagawa, Koto-ku, Tokyo 135-0051, Japan.

N2 Clinic Yotsuya, 5F 2-6 Samon-cho, Shinjuku-ku, Tokyo 160-0017, Japan.

Biomedicines. 2021 May 17;9(5):557. doi: 10.3390/biomedicines9050557.

Natural killer (NK) cells are cytotoxic immune cells with an innate capacity for eliminating cancer cells and virus- infected cells. NK cells are critical effector cells in the immunosurveillance of cancer and viral infections. Patients with low NK cell activity or NK cell deficiencies are predisposed to increased risks of cancer and severe viral infections. However, functional alterations of human NK cells are associated with lifestyles and aging. Personal lifestyles, such as cigarette smoking, alcohol consumption, stress, obesity, and aging are correlated with NK cell dysfunction, whereas adequate sleep, moderate exercise, forest bathing, and listening to music are associated with functional healthy NK cells. Therefore, adherence to a healthy lifestyle is essential and will be favorable for immunosurveillance of cancer and viral infections with healthy NK cells.

自然杀伤（NK）细胞是具有先天性能力消除癌细胞和病毒感染细胞的细胞毒性免疫细胞。NK细胞是癌症免疫监视和病毒感染中的关键效应细胞。NK细胞活性低或NK细胞缺陷的患者易患癌症和严重病毒感染的风险增加。然而，人类NK细胞的功能改变与生活方式和衰老有关。个人生活方式，如吸烟、饮酒、压力、肥胖和衰老与NK细胞功能障碍相关，而充足睡眠、适度运动、森林浴和听音乐与功能健康的NK细胞相关。因此，坚持健康的生活方式至关重要，将有利于通过健康的NK细胞对癌症和病毒感染进行免疫监视。