Mohammadnejad Javad, Yazdian Fatemeh, Omidi Meisam, Rostami Arash Darzian, Rasekh Behnam, Fathinia Atena
Department of Life Science Engineering Faculty of New Sciences and Technologies University of Tehran Tehran Iran.
Department of Tissue Engineering and Regenerative Medicine School of Advanced Technologies in Medicine Shahid Beheshti University of Medical sciences Tehran Iran.
Eng Life Sci. 2018 Mar 6;18(5):298-307. doi: 10.1002/elsc.201700138. eCollection 2018 May.
Recently, bacterial cellulose (BC) based wound dressing have raised significant interests in medical fields. However, to our best knowledge, it is apparent that the BC itself has no antibacterial activity. In this study, we optimized graphene oxide-silver (GO-Ag) nanohybrid synthesis using Response Surface Methodology and impregnate it to BC and carefully investigate their antibacterial activities against both the Gram-negative bacteria and the Gram-positive bacteria . We discover that, compared to silver nanoparticles, GO-Ag nanohybrid with an optimal GO suspension's pH and ratio is much more effective and shows synergistically enhanced, strong antibacterial activities at rather low dose. The GO-Ag nanohybrid is more toxic to than that to . The antibacterial and mechanical properties of BC/GO-Ag composite are further investigated.
近年来，基于细菌纤维素（BC）的伤口敷料在医学领域引起了广泛关注。然而，据我们所知，BC本身显然没有抗菌活性。在本研究中，我们使用响应面法优化了氧化石墨烯-银（GO-Ag）纳米杂化物的合成，并将其浸渍到BC中，仔细研究了它们对革兰氏阴性菌和革兰氏阳性菌的抗菌活性。我们发现，与银纳米颗粒相比，具有最佳GO悬浮液pH值和比例的GO-Ag纳米杂化物更有效，并且在相当低的剂量下显示出协同增强的强抗菌活性。GO-Ag纳米杂化物对[此处原文缺失具体比较对象]的毒性比对[此处原文缺失具体比较对象]的毒性更大。进一步研究了BC/GO-Ag复合材料的抗菌和力学性能。
