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消毒剂化学吸附于细菌纤维素敷料对慢性伤口分离病原体生物膜的体外疗效。

In Vitro Efficacy of Bacterial Cellulose Dressings Chemisorbed with Antiseptics against Biofilm Formed by Pathogens Isolated from Chronic Wounds.

机构信息

Department of Pharmaceutical Microbiology and Parasitology, Medical University of Wroclaw, 50-556 Wroclaw, Poland.

Faculty of Biological Sciences, University of Wroclaw, 51-148 Wroclaw, Poland.

出版信息

Int J Mol Sci. 2021 Apr 13;22(8):3996. doi: 10.3390/ijms22083996.

DOI:10.3390/ijms22083996
PMID:33924416
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8069587/
Abstract

Local administration of antiseptics is required to prevent and fight against biofilm-based infections of chronic wounds. One of the methods used for delivering antiseptics to infected wounds is the application of dressings chemisorbed with antimicrobials. Dressings made of bacterial cellulose (BC) display several features, making them suitable for such a purpose. This work aimed to compare the activity of commonly used antiseptic molecules: octenidine, polyhexanide, povidone-iodine, chlorhexidine, ethacridine lactate, and hypochlorous solutions and to evaluate their usefulness as active substances of BC dressings against 48 bacterial strains (8 species) and 6 yeast strains (1 species). A silver dressing was applied as a control material of proven antimicrobial activity. The methodology applied included the assessment of minimal inhibitory concentrations (MIC) and minimal biofilm eradication concentration (MBEC), the modified disc-diffusion method, and the modified antibiofilm dressing activity measurement (A.D.A.M.) method. While in 96-well plate-based methods (MIC and MBEC assessment), the highest antimicrobial activity was recorded for chlorhexidine, in the modified disc-diffusion method and in the modified A.D.A.M test, povidone-iodine performed the best. In an in vitro setting simulating chronic wound conditions, BC dressings chemisorbed with polyhexanide, octenidine, or povidone-iodine displayed a similar or even higher antibiofilm activity than the control dressing containing silver molecules. If translated into clinical conditions, the obtained results suggest high applicability of BC dressings chemisorbed with antiseptics to eradicate biofilm from chronic wounds.

摘要

局部应用防腐剂是预防和对抗慢性伤口生物膜感染的必要手段。将防腐剂递送到感染伤口的一种方法是应用化学吸附有抗菌剂的敷料。细菌纤维素 (BC) 敷料具有多种特性，使其非常适合这种用途。本工作旨在比较常用防腐剂分子的活性：聚己定、聚六亚甲基胍、聚维酮碘、洗必泰、乳酸依沙吖啶和次氯酸钠溶液，并评估它们作为 BC 敷料针对 48 种细菌株（8 种）和 6 种酵母株（1 种）的活性物质的有用性。银敷料作为具有证明抗菌活性的对照材料进行应用。所应用的方法学包括最小抑菌浓度 (MIC) 和最小生物膜清除浓度 (MBEC) 的评估、改良的圆盘扩散法和改良的抗生物膜敷料活性测量 (A.D.A.M.) 法。虽然在 96 孔板法（MIC 和 MBEC 评估）中，洗必泰显示出最高的抗菌活性，但在改良的圆盘扩散法和改良的 A.D.A.M. 试验中，聚维酮碘的表现最佳。在体外模拟慢性伤口条件的情况下，化学吸附有多聚己定、聚六亚甲基胍或聚维酮碘的 BC 敷料显示出与含有银分子的对照敷料相似甚至更高的抗生物膜活性。如果将这些结果转化为临床条件，那么所获得的结果表明，化学吸附有防腐剂的 BC 敷料在清除慢性伤口生物膜方面具有很高的适用性。

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