Naegeli Hanspeter, Birch Andrew Nicholas, Casacuberta Josep, De Schrijver Adinda, Gralak Mikołaj Antoni, Guerche Philippe, Jones Huw, Manachini Barbara, Messéan Antoine, Nielsen Elsa Ebbesen, Nogué Fabien, Robaglia Christophe, Rostoks Nils, Sweet Jeremy, Tebbe Christoph, Visioli Francesco, Wal Jean-Michel, Gennaro Andrea, Lanzoni Anna, Olaru Irina
EFSA J. 2017 Nov 28;15(11):e05000. doi: 10.2903/j.efsa.2017.5000. eCollection 2017 Nov.
In this opinion, the GMO Panel assessed the four-event stack maize 1507 × 59122 × MON810 × NK603 and its ten subcombinations, independently of their origin. The GMO Panel previously assessed the four single events combined in this four-event stack maize and five of their combinations and did not identify safety concerns. No new data on the single events or their previously assessed combinations leading to modification of the original conclusions were identified. Based on the molecular, agronomic, phenotypic and compositional characteristics, the combination of the single maize events and of the newly expressed proteins in the four-event stack maize did not give rise to food and feed safety or nutritional issues. The GMO Panel concludes that the four-event stack maize is as safe and as nutritious as its non-GM comparator. In the case of accidental release of viable grains of maize 1507 × 59122 × MON810 × NK603 into the environment, this would not raise environmental safety concerns. For four of the subcombinations not previously assessed, protein expression data were provided and did not indicate an interaction affecting the levels of the newly expressed proteins in these subcombinations. The five subcombinations not previously assessed are expected to be as safe as the single maize events, the previously assessed subcombinations and the four-event stack maize. The GMO Panel considers that post-market monitoring of maize 1507 × 59122 ×MON810 × NK603 and its subcombinations is not necessary. The post-market environmental monitoring plan and reporting intervals are in line with the intended uses of maize 1507 × 59122 × MON810 ×NK603 and its subcombinations.
在此意见中，转基因生物小组对四事件叠加玉米1507×59122×MON810×NK603及其十个亚组合进行了评估，不考虑其来源。转基因生物小组此前已对该四事件叠加玉米中所含的四个单一事件及其五个组合进行了评估，未发现安全问题。未发现导致修改原结论的关于单一事件或其先前评估组合的新数据。基于分子、农艺、表型和成分特征，四事件叠加玉米中单一玉米事件与新表达蛋白质的组合未引发食品和饲料安全或营养问题。转基因生物小组得出结论，四事件叠加玉米与其非转基因对照一样安全且营养。如果玉米1507×59122×MON810×NK603的活种子意外释放到环境中，这不会引发环境安全问题。对于四个先前未评估的亚组合，提供了蛋白质表达数据，未表明存在影响这些亚组合中新表达蛋白质水平的相互作用。预计五个先前未评估的亚组合与单一玉米事件、先前评估的亚组合以及四事件叠加玉米一样安全。转基因生物小组认为，对玉米1507×59122×MON810×NK603及其亚组合进行上市后监测没有必要。上市后环境监测计划和报告间隔符合玉米1507×59122×MON810×NK603及其亚组合的预期用途。
