Rychen Guido, Aquilina Gabriele, Azimonti Giovanna, Bampidis Vasileios, Bastos Maria de Lourdes, Bories Georges, Chesson Andrew, Cocconcelli Pier Sandro, Flachowsky Gerhard, Gropp Jürgen, Kolar Boris, Kouba Maryline, López Puente Secundino, López-Alonso Marta, Mantovani Alberto, Mayo Baltasar, Ramos Fernando, Saarela Maria, Villa Roberto Edoardo, Wallace Robert John, Wester Pieter, Dierick Noël Albert, Brantom Paul, Anguita Montserrat
EFSA J. 2017 Jul 21;15(7):e04942. doi: 10.2903/j.efsa.2017.4942. eCollection 2017 Jul.
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of HOSTAZYM X. The additive HOSTAZYM X is a preparation of endo-1,4-β-xylanase available in different liquid and solid formulations. This product is authorised as a feed additive for chickens for fattening, turkeys for fattening, laying hens, minor poultry species for fattening and laying, weaned piglets and pigs for fattening. The FEEDAP Panel adopted two opinions on the safety and efficacy of the product as a feed additive for poultry and pigs, and another one for its use as a feed additive in chickens reared for laying and minor poultry species reared for laying. The applicant has now requested to extend the authorisation to carps (). The FEEDAP Panel considered that the new use of the additive would not change the previous conclusions regarding the safety for the consumer, user and environment. The FEEDAP Panel concluded that there are no concerns for consumer safety and no risks for the environment are expected. Considering the safety for the user, it was concluded that the additive should be considered a potential skin and eye irritant, and a potential skin and respiratory sensitiser. The data in a tolerance trial performed with carps showed that the additive is safe for carp at 1,050 endo-pentosanase units (EPU)/kg feed. The results in three efficacy trials showed that the additive has the potential to improve the performance of the carps at 1,050 EPU/kg feed.
应欧盟委员会的要求，动物饲料添加剂及产品或物质专家小组（FEEDAP）被要求就HOSTAZYM X的安全性和有效性发表科学意见。添加剂HOSTAZYM X是一种内切-1,4-β-木聚糖酶制剂，有不同的液体和固体剂型。该产品被批准作为育肥鸡、育肥火鸡、产蛋鸡、育肥和产蛋的小型家禽、断奶仔猪和育肥猪的饲料添加剂。FEEDAP专家小组就该产品作为家禽和猪的饲料添加剂的安全性和有效性通过了两份意见，另一份是关于其作为产蛋鸡和产蛋小型家禽的饲料添加剂的使用意见。申请人现要求将授权范围扩大到鲤鱼（）。FEEDAP专家小组认为，该添加剂的新用途不会改变先前关于对消费者、使用者和环境安全性的结论。FEEDAP专家小组得出结论，不存在消费者安全问题，预计对环境也无风险。考虑到对使用者的安全性，得出的结论是该添加剂应被视为潜在的皮肤和眼睛刺激物以及潜在的皮肤和呼吸道致敏剂。在鲤鱼进行的耐受性试验数据表明，该添加剂在饲料中含量为1050内切戊聚糖酶单位（EPU）/千克时对鲤鱼是安全的。三项功效试验的结果表明，该添加剂在饲料中含量为1050 EPU/千克时有提高鲤鱼生长性能的潜力。
