Rychen Guido, Aquilina Gabriele, Azimonti Giovanna, Bampidis Vasileios, Bastos Maria de Lourdes, Bories Georges, Chesson Andrew, Cocconcelli Pier Sandro, Flachowsky Gerhard, Gropp Jürgen, Kolar Boris, Kouba Maryline, López-Alonso Marta, López Puente Secundino, Mantovani Alberto, Mayo Baltasar, Ramos Fernando, Saarela Maria, Villa Roberto Edoardo, Wallace Robert John, Wester Pieter, Brantom Paul, Dierick Noël Albert, Anguita Montserrat
EFSA J. 2018 Mar 28;16(3):e05216. doi: 10.2903/j.efsa.2018.5216. eCollection 2018 Mar.
ECONASE XT is an enzyme preparation with endo-1,4-β-xylanase which is authorised as a feed additive for chickens for fattening or reared for laying, turkeys for fattening or reared for breeding, laying hens, weaned piglets, pigs for fattening and minor poultry species. The authorisation of the additive for laying hens is at 24,000 BXU/kg feed. The applicant asked for a modification on the conditions of use in laying hens, which consists in the reduction of the minimum recommended level from 24,000 BXU/kg feed to 12,000 BXU/kg feed. In previous opinions, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) assessed the safety of the product when used as a feed additive and concluded that the use of the product as a feed additive raises no concerns for consumer safety and no risks for the environment are expected. The Panel also concluded that the additive is non-irritant to the skin, and the liquid form is non-irritant to the eyes and is not a dermal sensitiser; however, it is considered a respiratory sensitiser. Regarding the use of the additive in laying hens, the Panel concluded that under the conditions of use the additive is safe for laying hens and that it can be efficacious at 24,000 BXU/kg. The results of the studies previously assessed showed in two cases improvements on the efficacy at the dose of 12,000 BXU/kg or below. The applicant provided two new studies which showed improvements at the new recommended dose on the performance of the laying hens in one trial and on the energy content in another trial. Therefore, the Panel concluded that the additive has a potential to be efficacious as a zootechnical additive in laying hens at the dose of 12,000 BXU/kg feed.
ECONASE XT是一种含有内切-1,4-β-木聚糖酶的酶制剂，被批准用作育肥鸡或产蛋鸡、育肥火鸡或种用火鸡、产蛋母鸡、断奶仔猪、育肥猪及小型家禽的饲料添加剂。该添加剂在产蛋母鸡中的批准用量为每千克饲料24,000 BXU。申请人请求修改产蛋母鸡的使用条件，即将最低推荐用量从每千克饲料24,000 BXU降至12,000 BXU/kg饲料。在之前的意见中，动物饲料添加剂和产品或物质专家委员会（FEEDAP）评估了该产品作为饲料添加剂使用时的安全性，并得出结论：该产品作为饲料添加剂使用不会对消费者安全造成担忧，预计对环境也无风险。专家委员会还得出结论，该添加剂对皮肤无刺激性，液体形式对眼睛无刺激性且不是皮肤致敏剂；然而，它被认为是一种呼吸道致敏剂。关于该添加剂在产蛋母鸡中的使用，专家委员会得出结论，在使用条件下该添加剂对产蛋母鸡是安全的，并且在每千克饲料24,000 BXU时可能有效。之前评估的研究结果在两个案例中显示，在每千克饲料12,000 BXU或更低剂量时功效有所提高。申请人提供了两项新研究，其中一项试验表明，在新推荐剂量下对产蛋母鸡的生产性能有改善，另一项试验表明对能量含量有改善。因此，专家委员会得出结论，该添加剂在每千克饲料12,000 BXU的剂量下作为产蛋母鸡的动物营养添加剂有潜在的有效性。
