Rychen Guido, Aquilina Gabriele, Azimonti Giovanna, Bampidis Vasileios, Bastos Maria de Lourdes, Bories Georges, Chesson Andrew, Cocconcelli Pier Sandro, Flachowsky Gerhard, Gropp Jürgen, Kolar Boris, Kouba Maryline, López-Alonso Marta, López Puente Secundino, Mantovani Alberto, Mayo Baltasar, Ramos Fernando, Saarela Maria, Villa Roberto Edoardo, Wallace Robert John, Wester Pieter, Brantom Paul, Dierick Noël, Anguita Montserrat
EFSA J. 2017 Feb 8;15(2):e04708. doi: 10.2903/j.efsa.2017.4708. eCollection 2017 Feb.
The additive HOSTAZYM X contains endo-1,4-β-xylanase and it is available in solid and liquid forms. This additive is authorised for use in piglets and pigs for fattening, chickens and turkeys for fattening, laying hens, minor poultry species for fattening and laying. The applicant has requested to extend the use of the additive to chickens reared for laying and minor poultry species reared for laying at a dose range of 1,500-3,000 EPU/kg feed. Safety aspects regarding the use of this additive in feed including the safety for the consumers, for the users and for the environment were previously assessed. The FEEDAP Panel concluded that there are no concerns for the consumer safety and no risks for the environment are expected, the additive should be considered a potential skin and eye irritant, and a potential skin and respiratory sensitiser. The FEEDAP Panel is not aware of any new information that would lead it to reconsider the conclusions drawn previously. The FEEDAP Panel had previously evaluated a tolerance trial carried out with chickens for fattening where it was considered that the animals tolerated well the dose of 3,000 EPU/kg feed. In that assessment, the FEEDAP Panel also evaluated the efficacy of the product in chickens for fattening and concluded that the additive has the potential to be efficacious in chickens for fattening at the dose of 1,500 EPU/kg feed. The tolerance and efficacy data in chickens for fattening evaluated previously was considered relevant for the use in the new target category/species proposed by the applicant. Consequently, the conclusions on the safety and efficacy drawn for chickens for fattening were extended to chickens reared for laying and extrapolated to minor poultry species reared for laying.
添加剂HOSTAZYM X含有内切-1,4-β-木聚糖酶，有固体和液体两种形式。该添加剂已被批准用于仔猪、育肥猪、育肥鸡、育肥火鸡、产蛋母鸡、育肥小型家禽和产蛋小型家禽。申请人已请求将该添加剂的使用范围扩大到产蛋鸡和产蛋小型家禽，剂量范围为每千克饲料1500-3000 EPU。此前已对该添加剂在饲料中的使用安全性进行了评估，包括对消费者、使用者和环境的安全性。饲料添加剂和动物营养产品专家委员会得出结论，该添加剂对消费者安全无担忧，预计对环境无风险，但该添加剂应被视为潜在的皮肤和眼睛刺激物以及潜在的皮肤和呼吸道致敏剂。饲料添加剂和动物营养产品专家委员会不知道有任何新信息会使其重新考虑先前得出的结论。饲料添加剂和动物营养产品专家委员会此前评估了一项对育肥鸡进行的耐受性试验，认为动物对每千克饲料3000 EPU的剂量耐受性良好。在该评估中，饲料添加剂和动物营养产品专家委员会还评估了该产品在育肥鸡中的功效，并得出结论，该添加剂在每千克饲料1500 EPU的剂量下对育肥鸡可能有效。先前评估的育肥鸡的耐受性和功效数据被认为与申请人提议的新目标类别/物种的使用相关。因此，对育肥鸡的安全性和功效得出的结论扩展到了产蛋鸡，并外推到了产蛋小型家禽。
