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属于第20类化学品的8-巯基-对薄荷烷-3-酮和薄荷-1-烯-8-硫醇用作所有动物物种调味剂时的安全性和有效性。

Safety and efficacy of 8-mercapto--menthan-3-one and -menth-1-ene-8-thiol belonging to chemical group 20 when used as flavourings for all animal species.

作者信息

Bampidis Vasileios, Azimonti Giovanna, Bastos Maria de Lourdes, Christensen Henrik, Kouba Maryline, Kos Durjava Mojca, López-Alonso Marta, López Puente Secundino, Marcon Francesca, Mayo Baltasar, Pechová Alena, Petkova Mariana, Ramos Fernando, Sanz Yolanda, Villa Roberto Edoardo, Woutersen Ruud, Brantom Paul, Chesson Andrew, Westendorf Johannes, Gregoretti Lucilla, Manini Paola, Dusemund Birgit

出版信息

EFSA J. 2019 Jan 16;17(1):e05530. doi: 10.2903/j.efsa.2019.5530. eCollection 2019 Jan.

DOI:10.2903/j.efsa.2019.5530
PMID:32626076
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7009286/
Abstract

Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of two compounds belonging to chemical group 20 (aliphatic and aromatic mono- and di-thiols and mono-, di-, tri-, and polysulfides with or without additional oxygenated functional groups). 8-Mercapto--menthan-3-one [12.038] and -menth-1-ene-8-thiol [12.085] are currently authorised as flavours in food. The FEEDAP Panel concludes that the two compounds are safe for the target species at the proposed maximum use level (0.05 mg/kg complete feed). No safety concern would arise for the consumer from the use of 8-mercapto--menthan-3-one and -menth-1-ene-8-thiol up to the highest safe level in feedingstuffs for all animal species. Both compounds should be considered as irritants to skin and eyes, and 8-mercapto--menthan-3-one [12.038] also as irritant to the respiratory tract. No conclusions can be drawn on skin sensitisation potential. No environmental risk is foreseen for these compounds at the maximum proposed use level in feed. Since the two compounds are used as flavourings in food and their function is essentially the same as that in food, no further demonstration of efficacy is necessary.

摘要

应欧盟委员会的要求,动物饲料添加剂及产品或物质专家小组(FEEDAP)被要求就属于化学类别20的两种化合物(脂肪族和芳香族单硫醇和二硫醇以及含或不含其他氧化官能团的单硫化物、二硫化物、三硫化物和多硫化物)的安全性和有效性发表科学意见。8-巯基-对薄荷烷-3-酮[12.038]和对薄荷-1-烯-8-硫醇[12.085]目前被批准作为食品香料使用。FEEDAP小组得出结论,在所提议的最大使用水平(0.05毫克/千克全价饲料)下,这两种化合物对目标物种是安全的。在所有动物饲料中,按照最高安全水平使用8-巯基-对薄荷烷-3-酮和对薄荷-1-烯-8-硫醇,不会对消费者产生安全问题。这两种化合物都应被视为对皮肤和眼睛有刺激性,8-巯基-对薄荷烷-3-酮[12.038]还被视为对呼吸道有刺激性。关于皮肤致敏潜力无法得出结论。在饲料中提议的最大使用水平下,预计这些化合物不会产生环境风险。由于这两种化合物在食品中用作调味剂,其功能与在食品中的基本相同,因此无需进一步证明其有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f290/7009286/aa05a25b9e0a/EFS2-17-e05530-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f290/7009286/aa05a25b9e0a/EFS2-17-e05530-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f290/7009286/aa05a25b9e0a/EFS2-17-e05530-g001.jpg

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