Bampidis Vasileios, Azimonti Giovanna, Bastos Maria de Lourdes, Christensen Henrik, Durjava Mojca, Kouba Maryline, López-Alonso Marta, López Puente Secundino, Marcon Francesca, Mayo Baltasar, Pechová Alena, Petkova Mariana, Ramos Fernando, Sanz Yolanda, Villa Roberto Edoardo, Woutersen Ruud, Brantom Paul, Chesson Andrew, Westendorf Johannes, Manini Paola, Dusemund Birgit
EFSA J. 2023 Mar 8;21(3):e07868. doi: 10.2903/j.efsa.2023.7868. eCollection 2023 Mar.
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of 2-acetylfuran [13.054] and 2-pentylfuran [13.059] belonging to chemical group 14 (furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms), when used as sensory additives (flavourings) in feed for all animal species. 2-Acetylfuran [13.054] was tested in tolerance studies in chickens for fattening, weaned piglets and cattle for fattening. No adverse effects were observed in the tolerance studies at 10-fold the intended use level. The FEEDAP Panel concluded that 2-acetylfuran [13.054] is safe for these species at the proposed use level of 0.5 mg/kg and conclusions were extrapolated to all animal species. For 2-pentylfuran [13.059], the Panel concluded that it is safe at the proposed maximum use level in feed of 0.5 mg/kg. No safety concern would arise for the consumer from the use of 2-acetylfuran [13.054] and 2-pentylfuran [13.059] up to the proposed maximum use level in feed as flavourings. The additives should be considered as irritant to skin and eyes and the respiratory tract, and as dermal and respiratory sensitisers. The use of 2-acetylfuran [13.054] and 2-pentylfuran [13.059] as flavours in animal feed was not expected to pose a risk for the environment. Since the compounds under assessment are used in food as flavourings and their function in feed is essentially the same as that in food, no further demonstration of efficacy was considered necessary.
应欧盟委员会的要求,欧洲食品安全局(EFSA)被要求就化学组14(有或没有额外侧链取代基和杂原子的糠基和呋喃衍生物)中的2-乙酰基呋喃[13.054]和2-戊基呋喃[13.059]用作所有动物饲料的感官添加剂(调味剂)时的安全性和有效性发表科学意见。对育肥鸡、断奶仔猪和育肥牛进行了2-乙酰基呋喃[13.054]的耐受性研究。在预期使用水平的10倍剂量下的耐受性研究中未观察到不良影响。饲料添加剂和动物产品添加剂专家委员会得出结论,2-乙酰基呋喃[13.054]在建议的0.5毫克/千克使用水平下对这些物种是安全的,并且结论外推至所有动物物种。对于2-戊基呋喃[13.059],专家委员会得出结论,在饲料中建议的最大使用水平0.5毫克/千克下它是安全的。在饲料中使用2-乙酰基呋喃[13.054]和2-戊基呋喃[13.059]达到建议的最大使用水平作为调味剂,不会给消费者带来安全问题。这些添加剂应被视为对皮肤、眼睛和呼吸道有刺激性,以及皮肤和呼吸道致敏剂。预计在动物饲料中使用2-乙酰基呋喃[13.054]和2-戊基呋喃[13.059]作为调味剂不会对环境构成风险。由于所评估的化合物在食品中用作调味剂,并且它们在饲料中的功能与在食品中的基本相同,因此认为无需进一步证明其有效性。