Bampidis Vasileios, Azimonti Giovanna, Bastos Maria de Lourdes, Christensen Henrik, Dusemund Birgit, Kouba Maryline, Kos Durjava Mojca, López-Alonso Marta, López Puente Secundino, Marcon Francesca, Mayo Baltasar, Pechová Alena, Petkova Mariana, Sanz Yolanda, Villa Roberto Edoardo, Woutersen Ruud, Costa Lucio, Dierick Noël, Flachowsky Gerhard, Mantovani Alberto, Wallace John, Tarrés-Call Jordi, Ramos Fernando
EFSA J. 2019 Mar 4;17(3):e05611. doi: 10.2903/j.efsa.2019.5611. eCollection 2019 Mar.
The product subject of this assessment is l-valine produced by fermentation with a strain of (CGMCC 11675). It is intended to be used in feed and water for drinking for all animal species and categories. Owing to the uncertainties regarding the possible genetic modification of the original production strain, the FEEDAP Panel cannot conclude on the safety of the additive l-valine produced with . CGMCC 11675 for the target species, the consumers, the users and the environment. The FEEDAP Panel has concerns on the safety for the target animals of the simultaneous oral administration of valine-containing additives via feed and water for drinking. In the absence of data, the FEEDAP Panel cannot conclude on the potential of l-valine produced with CGMCC 11675 to be toxic by inhalation, irritant to skin or eyes, or on its potential to be a dermal sensitiser. The product is considered an efficacious source of the amino acid l-valine for all animal species. The supplemental l-valine requires protection against rumen degradations in order to be as efficacious in ruminant as in non-ruminant species.
本次评估的产品对象是由菌株（CGMCC 11675）发酵生产的L-缬氨酸。其拟用于所有动物种类的饲料和饮用水中。由于原始生产菌株可能存在基因改造的不确定性，饲料添加剂和动物营养产品欧洲小组无法就使用CGMCC 11675生产的添加剂L-缬氨酸对目标物种、消费者、使用者和环境的安全性得出结论。饲料添加剂和动物营养产品欧洲小组对通过饲料和饮用水同时口服含缬氨酸添加剂对目标动物的安全性表示关注。在缺乏数据的情况下，饲料添加剂和动物营养产品欧洲小组无法就使用CGMCC 11675生产的L-缬氨酸通过吸入产生毒性、对皮肤或眼睛产生刺激或具有皮肤致敏性的可能性得出结论。该产品被认为是所有动物种类的有效氨基酸L-缬氨酸来源。为了在反刍动物中与非反刍动物中一样有效，补充的L-缬氨酸需要防止瘤胃降解。
