Bampidis Vasileios, Azimonti Giovanna, Bastos Maria de Lourdes, Christensen Henrik, Dusemund Birgit, Fašmon Durjava Mojca, Kouba Maryline, López-Alonso Marta, López Puente Secundino, Marcon Francesca, Mayo Baltasar, Pechová Alena, Petkova Mariana, Ramos Fernando, Sanz Yolanda, Villa Roberto Edoardo, Woutersen Ruud, Cocconcelli Pier Sandro, Glandorf Boet, Prieto Maradona Miguel, Saarela Maria, Brozzi Rosella, Pettenati Elisa, Tarrés-Call Jordi
EFSA J. 2021 Apr 19;19(4):e06521. doi: 10.2903/j.efsa.2021.6521. eCollection 2021 Apr.
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of the feed additive consisting of l-valine produced by fermentation using a non-genetically modified strain of (CGMCC 7.366). The additive is intended to be used in feed and water for drinking for all animal species and categories. The production strain is considered suitable for the qualified presumption of safety (QPS) approach to safety assessment. The FEEDAP Panel concludes that l-valine produced using CGMCC 7.366 is safe for the target species when supplemented in appropriate amounts to the diet according to the nutritional needs of the target species. The FEEDAP Panel has concerns on the use of amino acids in water for drinking for hygienic reasons, and due to the risk of imbalances when administered simultaneously via feed. The use of l-valine produced using CGMCC 7.366 in animal nutrition is considered safe for the consumer and for the environment. No conclusion could be drawn on the potential of l-valine produced using CGMCC 7.366 to be toxic by inhalation, irritant to the skin or eyes, or a dermal sensitiser due to the lack of data. The additive l-valine produced by fermentation using CGMCC 7.366 is regarded as an efficacious source of the essential amino acid l-valine for non-ruminant nutrition. For the supplemental l-valine to be as efficacious in ruminants as in non-ruminant species, it requires protection against degradation in the rumen.
应欧盟委员会的要求，动物饲料添加剂及产品或物质专家小组（FEEDAP）被要求就一种由非转基因菌株（CGMCC 7.366）发酵生产的L-缬氨酸饲料添加剂的安全性和有效性发表科学意见。该添加剂拟用于所有动物种类和类别的饲料及饮用水中。生产菌株被认为适用于安全性评估的合格假定（QPS）方法。FEEDAP专家小组得出结论，按照目标物种的营养需求，以适当数量添加到日粮中时，使用CGMCC 7.366生产的L-缬氨酸对目标物种是安全的。出于卫生原因，以及由于通过饲料同时给药时存在失衡风险，FEEDAP专家小组对在饮用水中使用氨基酸表示关注。使用CGMCC 7.366生产的L-缬氨酸用于动物营养被认为对消费者和环境是安全的。由于缺乏数据，无法就使用CGMCC 7.366生产的L-缬氨酸通过吸入产生毒性、对皮肤或眼睛有刺激性或为皮肤致敏剂的可能性得出结论。使用CGMCC 7.366发酵生产的L-缬氨酸添加剂被视为非反刍动物营养中必需氨基酸L-缬氨酸的有效来源。要使补充的L-缬氨酸在反刍动物中与在非反刍动物物种中一样有效，需要防止其在瘤胃中降解。
