Bampidis Vasileios, Azimonti Giovanna, Bastos Maria de Lourdes, Christensen Henrik, Durjava Mojca, Dusemund Birgit, Kouba Maryline, López-Alonso Marta, Puente Secundino López, Marcon Francesca, Mayo Baltasar, Pechová Alena, Petkova Mariana, Ramos Fernando, Sanz Yolanda, Villa Roberto Edoardo, Woutersen Ruud, Herman Lieve, Anguita Montserrat, Tarrés-Call Jordi, Firmino Joana P
EFSA J. 2023 Jul 12;21(7):e08104. doi: 10.2903/j.efsa.2023.8104. eCollection 2023 Jul.
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l-valine produced by fermentation using a non-genetically modified strain of (CGMCC 18932). l-Valine is intended to be used in feed and water for drinking as a nutritional additive, functional group amino acids, their salts and analogues, for all animal species and categories. The production strain is considered suitable for the qualified presumption of safety (QPS) approach to safety assessment. The FEEDAP Panel concluded that l-valine produced by CGMCC 18932 is considered safe for the target species when supplemented to the diet in appropriate amounts according to the nutritional needs of the target species. The use of l-valine produced using CGMCC 18932 in animal nutrition is considered safe for the consumer and for the environment. No conclusion could be drawn on the potential of l-valine produced using CGMCC 18932 to be irritant to the skin or eyes, or a dermal sensitiser due to the lack of data. The FEEDAP Panel concluded that the l-valine produced by fermentation using CGMCC 18932 is an efficacious source of the essential amino acid l-valine for non-ruminant nutrition. To be as efficacious in ruminants as in non-ruminants, supplemental l-valine requires protection against ruminal degradation. The FEEDAP Panel expressed concerns on the use of amino acids in water for drinking for hygienic reasons.
应欧盟委员会的要求，欧洲食品安全局（EFSA）被要求就使用非转基因菌株（CGMCC 18932）发酵生产的L-缬氨酸的安全性和有效性发表科学意见。L-缬氨酸拟作为营养添加剂、功能性氨基酸及其盐类和类似物，用于所有动物种类和类别的饲料和饮用水中。生产菌株被认为适用于安全性评估的合格假定（QPS）方法。饲料添加剂和动物营养产品欧洲小组得出结论，根据目标物种的营养需求，以适当数量添加到日粮中时，CGMCC 18932生产的L-缬氨酸对目标物种被认为是安全的。在动物营养中使用CGMCC 18932生产的L-缬氨酸对消费者和环境被认为是安全的。由于缺乏数据，无法就CGMCC 18932生产的L-缬氨酸对皮肤或眼睛产生刺激或导致皮肤过敏的可能性得出结论。饲料添加剂和动物营养产品欧洲小组得出结论，使用CGMCC 18932发酵生产的L-缬氨酸是反刍动物营养中必需氨基酸L-缬氨酸的有效来源。为了在反刍动物中与在非反刍动物中一样有效，补充的L-缬氨酸需要防止瘤胃降解。出于卫生原因，饲料添加剂和动物营养产品欧洲小组对在饮用水中使用氨基酸表示担忧。
