Bampidis Vasileios, Azimonti Giovanna, Bastos Maria de Lourdes, Christensen Henrik, Dusemund Birgit, Kouba Maryline, Kos Durjava Mojca, López-Alonso Marta, López Puente Secundino, Marcon Francesca, Mayo Baltasar, Pechová Alena, Petkova Mariana, Ramos Fernando, Sanz Yolanda, Villa Roberto Edoardo, Woutersen Ruud, Herman Lieve, Glandorf Boet, Saarela Maria, Anguita Montserrat, Galobart Jaume, Holczknecht Orsolya, Tarrés-Call Jordi, Pettenati Elisa, Pizzo Fabiola, Manini Paola
EFSA J. 2019 May 2;17(5):e05696. doi: 10.2903/j.efsa.2019.5696. eCollection 2019 May.
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l-arginine produced by fermentation with a genetically modified strain of KCCM 80182 when used as a nutritional additive in feed and water for drinking for all animal species categories. Viable cells of the production strain and its recombinant DNA were not detected in the additive. The product l-arginine, manufactured by fermentation with , KCCM 80182, does not give rise to any safety concern with regard to the production strain. l-Arginine produced using KCCM 80182 is considered safe for the target species. The FEEDAP Panel has concerns regarding the safety of the simultaneous oral administration of l-arginine via water for drinking and feed. l-Arginine produced using KCCM 80182 is safe for the consumer and for the environment. The additive is not hazardous by inhalation, is not a skin sensitiser, but is corrosive to skin and eyes. The product under assessment is considered an efficacious source of the amino acid l-arginine for all animal species. For l-arginine to be as efficacious in ruminants as in non-ruminant species, it requires protection against microbial degradation in the rumen.
应欧盟委员会的要求，动物饲料添加剂及产品或物质专家小组（FEEDAP）被要求就使用基因改造的KCCM 80182菌株发酵生产的L-精氨酸用作所有动物种类的饲料和饮用水中的营养添加剂提供科学意见。在该添加剂中未检测到生产菌株的活细胞及其重组DNA。使用KCCM 80182发酵生产的L-精氨酸产品，就生产菌株而言不会引起任何安全问题。使用KCCM 80182生产的L-精氨酸对目标物种被认为是安全的。FEEDAP专家小组对通过饮用水和饲料同时口服L-精氨酸的安全性表示关注。使用KCCM 80182生产的L-精氨酸对消费者和环境是安全的。该添加剂吸入无危害，不是皮肤致敏剂，但对皮肤和眼睛有腐蚀性。所评估的产品被认为是所有动物种类的氨基酸L-精氨酸的有效来源。为使L-精氨酸在反刍动物中与在非反刍动物中一样有效，它需要防止在瘤胃中被微生物降解。
