Bampidis Vasileios, Azimonti Giovanna, Bastos Maria de Lourdes, Christensen Henrik, Dusemund Birgit, Kouba Maryline, Kos Durjava Mojca, López-Alonso Marta, López Puente Secundino, Marcon Francesca, Mayo Baltasar, Pechová Alena, Petkova Mariana, Ramos Fernando, Sanz Yolanda, Villa Roberto Edoardo, Woutersen Ruud, Costa Lucio, Dierick Noël, Flachowsky Gerhard, Glandorf Boet, Herman Lieve, Mantovani Alberto, Saarela Maria, Anguita Montserrat, Tarrés-Call Jordi, Wallace Robert John
EFSA J. 2019 Mar 1;17(3):e05603. doi: 10.2903/j.efsa.2019.5603. eCollection 2019 Mar.
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l-threonine produced by fermentation with ■■■■■ when used as nutritional additive in feed and water for drinking for all animal species and categories. The product under assessment is l-threonine produced by fermentation with a genetically modified strain of (■■■■■). The production strain and its recombinant DNA were not detected in the additive. The product l-threonine, manufactured by fermentation with , ■■■■■ does not give rise to any safety concern with regard to the production strain. l-Threonine produced using ■■■■■ is considered safe for the target species. The FEEDAP Panel has concerns regarding the safety of the simultaneous oral administration of l-threonine via water for drinking and feed. l-Threonine produced using ■■■■■ is safe for the consumer. The additive is not a skin or eye irritant and is not a skin sensitiser. Although the workers can be exposed by inhalation, the results of an acute inhalation study showed that risk of adverse effects by inhalation is low. l-Threonine produced using ■■■■■ is safe for the environment. The product under assessment is considered an efficacious source of the amino acid l-threonine for all animal species. For l-threonine to be as efficacious in ruminants as in non-ruminant species, it requires protection against degradation in the rumen.
应欧盟委员会的要求，动物饲料添加剂及产品或物质专家小组（FEEDAP）被要求就使用■■■■■发酵生产的L-苏氨酸作为所有动物种类和类别的饲料及饮用水中的营养添加剂提供科学意见。所评估的产品是使用转基因菌株（■■■■■）发酵生产的L-苏氨酸。在添加剂中未检测到生产菌株及其重组DNA。使用■■■■■发酵生产的产品L-苏氨酸在生产菌株方面不会引起任何安全问题。使用■■■■■生产的L-苏氨酸对目标物种被认为是安全的。FEEDAP专家小组对通过饮用水和饲料同时口服L-苏氨酸的安全性表示关注。使用■■■■■生产的L-苏氨酸对消费者是安全的。该添加剂不是皮肤或眼睛刺激物，也不是皮肤致敏剂。虽然工人可能通过吸入接触，但急性吸入研究结果表明，吸入产生不良反应的风险较低。使用■■■■■生产的L-苏氨酸对环境是安全的。所评估的产品被认为是所有动物种类的有效L-苏氨酸氨基酸来源。为使L-苏氨酸在反刍动物中与在非反刍动物物种中一样有效，需要对其在瘤胃中的降解进行保护。
