糖尿病、肥胖与 COVID-19：复杂的相互作用。
Diabetes, obesity and COVID-19: A complex interplay.
机构信息
Department of Diabetes, King's College NHS Foundation Trust, London, UK.
King's Health Partners' Institute of Diabetes, Endocrinology and Obesity, London, UK.
出版信息
Diabetes Obes Metab. 2020 Oct;22(10):1892-1896. doi: 10.1111/dom.14134. Epub 2020 Jul 28.
Abstract
With the accumulation of observational data showing an association of metabolic co-morbidities with adverse outcomes from COVID-19, there is a need to disentangle the contributions of pre-existing macro- and microvascular disease, obesity and glycaemia. This article outlines the complex mechanistic and clinical interplay between diabetes and COVID-19, the clinical and research questions which arise from this relationship, and the types of studies needed to answer those questions. The authors are clinicians and academics working in diabetes and obesity medicine, but the article is pitched to an audience of generalists with clinical experience of or interest in the management of COVID-19.
摘要
随着越来越多的观察性数据表明代谢合并症与 COVID-19 的不良结局之间存在关联，因此需要厘清先前存在的大血管和微血管疾病、肥胖症和血糖之间的作用。本文概述了糖尿病和 COVID-19 之间复杂的机制和临床相互作用，以及由此产生的临床和研究问题，以及回答这些问题所需的研究类型。作者是从事糖尿病和肥胖症医学的临床医生和学者，但本文面向的是具有 COVID-19 管理临床经验或对此感兴趣的普通科医生。
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