[一种来自芍药根的新木脂苷]

[A new lignan glucoside from root of Paeonia lactiflora].

作者信息

Zhong Wan-Chao, Li Rui, Xia Huan, Xia Gui-Yang, Zhang Jing-Fang, Tian Gui-Hua, Lin Sheng

机构信息

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050, China.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050, China Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital,Beijing University of Chinese Medicine Beijing 100700, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2020 Jun;45(12):2903-2906. doi: 10.19540/j.cnki.cjcmm.20200328.203.

DOI:10.19540/j.cnki.cjcmm.20200328.203

PMID:32627465

Abstract

A new lignan glucoside,(+)-fragransin A_2-4-O-β-D-glucopyranoside(1), has been isolated from the dry root of Paeonia lactiflora by column chromatography on silica gel, Sephadex LH-20, and MCI-gel resin, as well as preparative RP-HPLC. The structure of the new compound was elucidated by spectroscopic data analysis(MS, UV, IR, CD, 1 D and 2 D NMR) and chemical method. Compound 1 showed moderate inhibition against lipopolysaccharide induced nitric oxide production in RAW264.7 macrophages, with an IC_(50) value of 21.3 μmol·L~(-1).

摘要

通过硅胶柱色谱、葡聚糖凝胶LH - 20和MCI - 凝胶树脂柱色谱以及制备型反相高效液相色谱法，从芍药的干燥根中分离得到一种新的木脂素苷，即(+)-fragransin A_2 - 4 - O-β - D - 吡喃葡萄糖苷(1)。通过光谱数据分析(质谱、紫外光谱、红外光谱、圆二色光谱、一维和二维核磁共振)和化学方法确定了该新化合物的结构。化合物1对脂多糖诱导RAW264.7巨噬细胞产生一氧化氮具有中等程度的抑制作用，IC_(50)值为21.3 μmol·L~(-1)。