白芍中的生物活性新木脂素和木脂素。

Bioactive neolignans and lignans from the roots of Paeonia lactiflora.

机构信息

Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

出版信息

Chin J Nat Med. 2022 Mar;20(3):210-214. doi: 10.1016/S1875-5364(22)60164-X.

DOI:10.1016/S1875-5364(22)60164-X

PMID:35369965

Abstract

Two new neolignans and one new lignan (1-3) were obtained from the roots of Paeonia lactiflora. Their structures were unambiguously elucidated based on extensive spectroscopic analysis, single-crystal X-ray crystallography, and the calculated and experimental electronic circular dichroism (ECD) spectra. Compound 1 was a racemic mixture and successfully resolved into the anticipated enantiomers via chiral-phase HPLC. Compound 3 demonstrated moderate inhibitory activity against human carboxylesterase 2A1 (hCES2A1) with an IC value of 7.28 ± 0.94 μmol·.

摘要

从芍药根部分离得到两个新的木脂素和一个新的木脂烷（1-3）。根据广泛的光谱分析、单晶 X 射线晶体学以及计算和实验电子圆二色谱（ECD）光谱，明确阐明了它们的结构。化合物 1 为外消旋混合物，并通过手性相 HPLC 成功拆分出预期的对映体。化合物 3 对人羧酸酯酶 2A1（hCES2A1）表现出中等抑制活性，IC 值为 7.28±0.94 μmol·。