Li Xiao-Qi, Wang Qi, Chen Yan
Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing 210028, China Multi-component of Traditional Chinese Medicine and Microecology Research Center,Jiangsu Provincial Academy of Chinese Medicine Nanjing 210028, China.
Zhongguo Zhong Yao Za Zhi. 2020 Jun;45(11):2540-2545. doi: 10.19540/j.cnki.cjcmm.20200328.302.
In this study, the contents of Cu, As, Cd, Pb and Hg in 10 batches of Gardeniae Fructus and 10 batches of fried Gardeniae Fructus from Fuzhou in Jiangxi were determined by inductively coupled plasma mass spectrometry(ICP-MS), and the target hazard coefficient(THQ) for different drug users(adults and children) was calculated by using the international health risk assessment model. According to the ISO and green industry standard, the content of Hg in 4 batches of Gardeniae Fructus exceeded the standard with an over-standard rate of 40%. The THQ and total THQ of Hg in 2 batches of Gardeniae Fructus were higher than the international standard limit of Gardeniae Fructus. For 10 batches of fried Gardeniae Fructus, the content of every heavy metal and total amount of five heavy metals did not exceed the standard. However, the THQ and total THQ of Hg in 1 batch of fried Gardeniae Fructus were higher than the international standard limit of Gardeniae Fructus. As compared with Gardeniae Fructus, the contents of Cu, Pb and Hg in fried Gardeniae Fructus decreased by 34.0%, 77.6% and 23.1%; the THQ of Cu, Pb and Hg for adults decreased by 33.3%, 75.0% and 96.9%; and the THQ of Cu, Pb and Hg for children decreased by 37.5%, 75.0%, 90.7%. It showed that the contents of heavy metals in individual batches of Gardeniae Fructus in this experiment had a certain risk to human health, but the contents of these heavy metals in fried Gardeniae Fructus had no obvious effect on human health. This study provided experimental basis and research ideas for safety evaluation of Gardeniae Fructus and fried Gardeniae Fructus.
本研究采用电感耦合等离子体质谱法（ICP-MS）测定了江西抚州10批次栀子和10批次炒栀子中铜、砷、镉、铅和汞的含量，并运用国际健康风险评估模型计算了不同用药人群（成人和儿童）的目标危害系数（THQ）。依据ISO和绿色产业标准，4批次栀子中汞含量超标，超标率为40%。2批次栀子中汞的THQ及总THQ高于栀子国际标准限值。10批次炒栀子中，各重金属含量及五种重金属总量均未超标。然而，1批次炒栀子中汞的THQ及总THQ高于栀子国际标准限值。与栀子相比，炒栀子中铜、铅和汞的含量分别降低了34.0%、77.6%和23.1%；成人铜、铅和汞的THQ分别降低了33.3%、75.0%和96.9%；儿童铜、铅和汞的THQ分别降低了37.5%、75.0%、90.7%。结果表明，本实验中个别批次栀子的重金属含量对人体健康有一定风险，但炒栀子中这些重金属含量对人体健康无明显影响。本研究为栀子和炒栀子的安全性评价提供了实验依据和研究思路。
