獐牙菜属中具有免疫抑制作用的苯-C 取代阿朴啡生物碱。
Immune-inhibitive phenyl-C substituent aporphine alkaloids from Thalictrum cirrhosum.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming 6505000, PR China.
出版信息
Fitoterapia. 2018 Jul;128:247-252. doi: 10.1016/j.fitote.2018.05.030. Epub 2018 May 28.
Five new phenyl-C substituent aporphine alkaloids, 6aR-2'-methoxycarbonyl-thaliadin (1), 6aR-2'-carboxyl-thaliadin (2), 6aR-3-methoxy-hernandalinol (3), 6aS-1,3,10-trimethoxy-natalamine (4), and 3-methoxy-2'-methoxycarbonyl-oxohernandalincin (5), together with sixteen known isoquinoline alkaloids (6-21) were isolated from the whole herb of Thalictrum cirrhosum (Levl.). Their structures were elucidated by extensive spectroscopic measurements, and six isoquinoline alkaloids showed significant inhibitory activity on concanavalin A-stimulated splenocytes proliferation with IC values 36-44 μM by the immunosuppressive bioassay.
从陕西唐古特乌头全草中分离得到五个新的苯甲酰基阿朴啡类生物碱
6aR-2′-甲氧羰基唐松辛定（1）、6aR-2′-羧基唐松辛定（2）、6aR-3-甲氧基赫尔曼丁醇（3）、6aS-1,3,10-三甲氧基纳塔林（4）和 3-甲氧基-2′-甲氧羰基-氧代赫尔曼丁辛宁（5），以及十六个已知的异喹啉生物碱（6-21）。通过广泛的光谱测量确定了它们的结构，其中六个异喹啉生物碱在免疫抑制生物测定中表现出对刀豆蛋白 A 刺激的脾细胞增殖的显著抑制活性，IC 值为 36-44 μM。
Zotero 插件