State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming 6505000, PR China.
Fitoterapia. 2018 Jul;128:247-252. doi: 10.1016/j.fitote.2018.05.030. Epub 2018 May 28.
Five new phenyl-C substituent aporphine alkaloids, 6aR-2'-methoxycarbonyl-thaliadin (1), 6aR-2'-carboxyl-thaliadin (2), 6aR-3-methoxy-hernandalinol (3), 6aS-1,3,10-trimethoxy-natalamine (4), and 3-methoxy-2'-methoxycarbonyl-oxohernandalincin (5), together with sixteen known isoquinoline alkaloids (6-21) were isolated from the whole herb of Thalictrum cirrhosum (Levl.). Their structures were elucidated by extensive spectroscopic measurements, and six isoquinoline alkaloids showed significant inhibitory activity on concanavalin A-stimulated splenocytes proliferation with IC values 36-44 μM by the immunosuppressive bioassay.
6aR-2′-甲氧羰基唐松辛定（1）、6aR-2′-羧基唐松辛定（2）、6aR-3-甲氧基赫尔曼丁醇（3）、6aS-1,3,10-三甲氧基纳塔林（4）和 3-甲氧基-2′-甲氧羰基-氧代赫尔曼丁辛宁（5），以及十六个已知的异喹啉生物碱（6-21）。通过广泛的光谱测量确定了它们的结构，其中六个异喹啉生物碱在免疫抑制生物测定中表现出对刀豆蛋白 A 刺激的脾细胞增殖的显著抑制活性，IC 值为 36-44 μM。
