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以患者为中心的采样技术的发展是临床试验的一项推动技术。

The development of patient-centric sampling as an enabling technology for clinical trials.

机构信息

Pharmacokinetics, Pharmacodynamics & Drug Metabolism, Merck & Co., Inc. West Point, PA 19486, USA.

出版信息

Bioanalysis. 2020 Jul;12(13):971-976. doi: 10.4155/bio-2020-0075. Epub 2020 Jul 6.

Abstract

Accessing patient samples using a whenever/wherever paradigm is needed to enable a better understanding of human biology and disease. The technology for convenient self-collection of blood samples by patients at home is quickly becoming available. The potential benefits of patient-centric sampling far outweigh the short-term challenges associated with implementation of this disruptive approach. This is especially true given we are amid a global pandemic and enabling patients to sample at home would help not only clinical trials, but healthcare in general. This perspective article aims to convince the reader that patient-centric sampling is a reality and that we are on the cusp of an information revolution in clinical trials that will be enabled by patient-centric (e.g., at home) sampling.

摘要

利用随时随地的模式获取患者样本,有助于更好地了解人类生物学和疾病。患者在家中方便地自行采集血样的技术正在迅速普及。以患者为中心的采样具有巨大的潜在益处,远远超过采用这种颠覆性方法所带来的短期挑战。鉴于我们正处于全球大流行之中,使患者能够在家中采样不仅有助于临床试验,而且有助于整个医疗保健行业,这一点尤其正确。本文旨在说服读者相信以患者为中心的采样已经成为现实,并且我们正处于临床试验信息革命的边缘,这种革命将得益于以患者为中心(例如在家中)的采样。

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