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Protective effects of 4-aminopyridine in experimental optic neuritis and multiple sclerosis.4- 氨基吡啶在实验性视神经炎和多发性硬化症中的保护作用。
Brain. 2020 Apr 1;143(4):1127-1142. doi: 10.1093/brain/awaa062.
2
Assessment of Clinically Meaningful Improvements in Self-Reported Walking Ability in Participants with Multiple Sclerosis: Results from the Randomized, Double-Blind, Phase III ENHANCE Trial of Prolonged-Release Fampridine.评估多发性硬化症患者自我报告行走能力的临床有意义改善：来自延长释放型苯丙胺的随机、双盲、III 期 ENHANCE 试验的结果。
CNS Drugs. 2019 Jan;33(1):61-79. doi: 10.1007/s40263-018-0586-5.
3
4-Aminopyridine ameliorates relapsing remitting experimental autoimmune encephalomyelitis in SJL/J mice.4-氨基吡啶可改善 SJL/J 小鼠的复发缓解型实验性自身免疫性脑脊髓炎。
J Neuroimmunol. 2018 Oct 15;323:131-135. doi: 10.1016/j.jneuroim.2018.08.007. Epub 2018 Aug 18.
4
Suppression of Inflammatory Demyelinaton and Axon Degeneration through Inhibiting Kv3 Channels.通过抑制Kv3通道抑制炎性脱髓鞘和轴突退变
Front Mol Neurosci. 2017 Oct 26;10:344. doi: 10.3389/fnmol.2017.00344. eCollection 2017.
5
Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis.多发性硬化症中的视网膜层分割：系统评价和荟萃分析。
Lancet Neurol. 2017 Oct;16(10):797-812. doi: 10.1016/S1474-4422(17)30278-8. Epub 2017 Sep 12.
6
Improved patient-reported health impact of multiple sclerosis: The ENABLE study of PR-fampridine.多发性硬化症患者报告的健康影响改善：PR-氨吡啶的ENABLE研究
Mult Scler. 2016 Jun;22(7):944-54. doi: 10.1177/1352458515606809. Epub 2015 Oct 7.
7
Optical coherence tomography reflects brain atrophy in multiple sclerosis: A four-year study.光学相干断层扫描反映多发性硬化症中的脑萎缩：一项为期四年的研究。
Ann Neurol. 2015 Nov;78(5):801-13. doi: 10.1002/ana.24487. Epub 2015 Oct 1.
8
Sustained-release oral fampridine in multiple sclerosis: a randomised, double-blind, controlled trial.缓释口服法吡酯治疗多发性硬化症：一项随机、双盲、对照试验
Lancet. 2009 Feb 28;373(9665):732-8. doi: 10.1016/S0140-6736(09)60442-6.
9
The use of 4-aminopyridine (fampridine) in demyelinating disorders.4-氨基吡啶（法吡拉定）在脱髓鞘疾病中的应用。
CNS Drug Rev. 2004 Winter;10(4):295-316. doi: 10.1111/j.1527-3458.2004.tb00029.x.
10
Identification of a new class of inhibitors of the voltage-gated potassium channel, Kv1.3, with immunosuppressant properties.鉴定一类具有免疫抑制特性的新型电压门控钾通道Kv1.3抑制剂。
Biochemistry. 2002 Jun 18;41(24):7781-94. doi: 10.1021/bi025722c.

4-aminopyridine is not just a symptomatic therapy, it has a neuroprotective effect - Yes.

作者信息

Strijbis Eva Mm, Nij Bijvank Jenny A, Killestein Joep

机构信息

Department of Neurology, MS Center Amsterdam, Amsterdam UMC, Location VUmc, Amsterdam, The Netherlands.

Department of Neurology, MS Center Amsterdam, Amsterdam UMC, Location VUmc, Amsterdam, The Netherlands/Department of Ophthalmology, Amsterdam UMC, Location VUmc, Amsterdam, The Netherlands.

出版信息

Mult Scler. 2020 Oct;26(11):1309-1310. doi: 10.1177/1352458520923951. Epub 2020 Jul 6.

DOI:10.1177/1352458520923951
PMID:32628062
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7543014/
Abstract
摘要