Opt Lett. 2019 Dec 15;44(24):5937-5940. doi: 10.1364/OL.44.005937.
Whispering gallery mode resonator lasers hold the promise of an ultralow intrinsic limit of detection. However, the widespread use of these devices for biosensing applications has been hindered by the complexity and lack of robustness of the proposed configurations. In this work, we demonstrate biosensing with an integrated microdisk laser. doped with was utilized because of its low optical losses as well as its emission in the range 1020-1050 nm, outside the absorption band of water. Single-mode laser emission was obtained at a wavelength of 1024 nm with a linewidth of 250 kHz while the microdisk cavity was submerged in water. A limit of detection of 300 pM (3.6 ng/ml) of the protein rhS100A4 in urine was experimentally demonstrated, showing the potential of the proposed devices for biosensing.
whispering gallery mode resonator 激光器有望实现超低的固有检测极限。然而，由于所提出的配置的复杂性和缺乏稳健性，这些设备在生物传感应用中的广泛使用受到了阻碍。在这项工作中，我们展示了一种集成微盘激光器的生物传感。掺 的原因是其光学损耗低，以及其在 1020-1050nm 范围内的发射，在水的吸收带之外。当微盘腔浸没在水中时，在 1024nm 波长处获得了线宽为 250kHz 的单模激光发射。实验证明，在尿液中的蛋白质 rhS100A4 的检测限为 300pM（3.6ng/ml），这表明了所提出的器件在生物传感中的潜力。
