Ryabova M A, Shumilova N A, Georgieva L V
Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia.
Vestn Otorinolaringol. 2020;85(3):52-56. doi: 10.17116/otorino20208503152.
To evaluate the role of secretory immunoglobulin E in the differential diagnosis of rhinitis in pregnant women.
The study involved 97 pregnant women with rhinitis symptoms and 23 healthy pregnant women without rhinitis symptoms. The first group of the study included 37 pregnant women with previously confirmed (anamnestically and immunologically) allergic rhinitis (AR), the 2nd group of the study included 30 pregnant women with suspected beginning of the AR, the 3rd group of the study was 30 women with pregnant women's rhinitis, diagnosed on the base of follow-up study. The study included: anamnesis taking, routine examination of ENT organs, general clinical examination, study of the level of total IgE in blood, nasal secretion cytology study, secretory IgE level in nasal secretion analysis, follow-up telephone gathered catamnestic data analysis.
When analyzing laboratory data, an increase in the average number of eosinophils in the blood was not detected in any group. When examining secretory immunoglobulin E of the nasal secretion in the group of patients with previously confirmed AR, this indicator averaged 2.9±0.7 kE/L, in the group with AR beginning - 5.5±2.6 kE/L, which exceeded the value in the control group (1.2±0.6 kE/l, <0.05). In the group of patients with pregnant women's rhinitis, the indices of nasal IgE did not differ significantly from the control group (1.9±0.3 and 1.2±0.6 kE/L, respectively, <0.05).
The level of secretory nasal immunoglobulin E can be used in the differential diagnosis of rhinitis in pregnancy.
评估分泌型免疫球蛋白E在孕妇鼻炎鉴别诊断中的作用。
该研究纳入了97例有鼻炎症状的孕妇和23例无鼻炎症状的健康孕妇。研究的第一组包括37例先前已确诊（通过既往史和免疫学检查）为过敏性鼻炎（AR）的孕妇，第二组包括30例疑似AR初发的孕妇，第三组是30例经随访研究确诊为妊娠性鼻炎的孕妇。研究内容包括：采集病史、耳鼻喉器官常规检查、全身临床检查、血液中总IgE水平研究、鼻分泌物细胞学研究、鼻分泌物中分泌型IgE水平分析、随访电话收集产后资料数据分析。
分析实验室数据时，未在任何一组中检测到血液中嗜酸性粒细胞平均数量增加。在先前确诊为AR的患者组中检测鼻分泌物的分泌型免疫球蛋白E时，该指标平均为2.9±0.7 kE/L，在AR初发组中为5.5±2.6 kE/L，超过了对照组的值（1.2±0.6 kE/l，P<0.05）。在妊娠性鼻炎患者组中，鼻IgE指标与对照组差异无统计学意义（分别为1.9±0.3和1.2±0.6 kE/L，P<0.05）。
鼻分泌型免疫球蛋白E水平可用于孕期鼻炎的鉴别诊断。
