Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA; Edith Nourse Rogers Memorial Veterans Hospital, Department of Neuropsychology, Bedford, MA, USA.
Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA; VA Boston Healthcare System, Boston, MA, USA; Department of Veterans Affairs Medical Center, Bedford, MA, USA.
Alzheimers Dement. 2019 May;15(5):686-698. doi: 10.1016/j.jalz.2018.12.015. Epub 2019 Mar 7.
Recent research with neuropathologic or biomarker evidence of Alzheimer's disease (AD) casts doubt on traumatic brain injury (TBI) as a risk factor for AD. We leveraged the National Alzheimer's Coordinating Center to examine the association between self-reported TBI with loss of consciousness and AD neuropathologic changes, and with baseline and longitudinal clinical status.
The sample included 4761 autopsy participants (453 with remote TBI with loss of consciousness; 2822 with AD neuropathologic changes) from National Alzheimer's Coordinating Center.
Self-reported TBI did not predict AD neuropathologic changes (P > .10). Reported TBI was not associated with baseline or change in dementia severity or cognitive function in participants with or without autopsy-confirmed AD.
Self-reported TBI with loss of consciousness may not be an independent risk factor for clinical or pathological AD. Research that evaluates number and severity of TBIs is needed to clarify the neuropathological links between TBI and dementia documented in other large clinical databases.
最近的研究发现，具有阿尔茨海默病（AD）的神经病理学或生物标志物证据的患者，对创伤性脑损伤（TBI）是否为 AD 的风险因素产生了怀疑。我们利用国家阿尔茨海默病协调中心，研究了自我报告的 TBI 与意识丧失以及 AD 神经病理变化之间的关联，并研究了基线和纵向临床状况。
该样本包括来自国家阿尔茨海默病协调中心的 4761 名尸检参与者（453 名有 TBI 导致的意识丧失；2822 名有 AD 神经病理变化）。
自我报告的 TBI 并不能预测 AD 神经病理变化（P>.10）。在有或没有尸检证实 AD 的参与者中，报告的 TBI 与基线或痴呆严重程度或认知功能的变化均无关。
有或无意识丧失的自我报告 TBI 可能不是临床或病理性 AD 的独立危险因素。需要研究评估 TBI 的数量和严重程度，以阐明在其他大型临床数据库中记录的 TBI 和痴呆之间的神经病理学联系。
