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通过参考接触过敏原或血小板活化因子的病理后遗症对预防性抗哮喘药物进行药理学评估。

Pharmacological evaluation of prophylactic anti-asthma drugs by reference to the pathological sequelae of exposure to allergen or platelet activating factor.

作者信息

Morley J, Sanjar S, Boubekeur K, Aoki S, Kristersson A

机构信息

Sandoz AG, Preclinical Research, Basle, Switzerland.

出版信息

Agents Actions Suppl. 1988;23:187-94. doi: 10.1007/978-3-0348-9156-1_13.

DOI:10.1007/978-3-0348-9156-1_13
PMID:3262989
Abstract

Exposure of guinea-pigs to platelet activating factor (PAF) induces airway hyperreactivity and causes an influx of eosinophils into the airways. These effects are inhibited by the established prophylactic anti-asthma drugs; cromoglycate, aminophylline, glucocorticosteroids and ketotifen, whereas other drug categories, with the exception of PAF-receptor antagonists, are ineffective.

摘要

将豚鼠暴露于血小板活化因子（PAF）会诱发气道高反应性，并导致嗜酸性粒细胞流入气道。这些效应会被已有的预防性抗哮喘药物抑制，如色甘酸、氨茶碱、糖皮质激素和酮替芬，而其他药物类别（除PAF受体拮抗剂外）则无效。

相似文献

1
Pharmacological evaluation of prophylactic anti-asthma drugs by reference to the pathological sequelae of exposure to allergen or platelet activating factor.通过参考接触过敏原或血小板活化因子的病理后遗症对预防性抗哮喘药物进行药理学评估。
Agents Actions Suppl. 1988;23:187-94. doi: 10.1007/978-3-0348-9156-1_13.
2
The effect of prophylactic anti-asthma drugs on PAF-induced airway hyperreactivity.
Jpn J Pharmacol. 1989 Oct;51(2):151-60. doi: 10.1254/jjp.51.151.
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Prevention of non-specific airway hyperreactivity after allergen challenge in guinea-pigs by the PAF receptor antagonist SDZ 64-412.血小板活化因子受体拮抗剂SDZ 64 - 412对豚鼠变应原激发后非特异性气道高反应性的预防作用
Br J Pharmacol. 1990 Feb;99(2):396-400. doi: 10.1111/j.1476-5381.1990.tb14715.x.
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Inhibition of PAF-induced eosinophil accumulation in pulmonary airways of guinea pigs by anti-asthma drugs.抗哮喘药物对血小板活化因子诱导的豚鼠肺气道嗜酸性粒细胞聚集的抑制作用。
Jpn J Pharmacol. 1989 Oct;51(2):167-72. doi: 10.1254/jjp.51.167.
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Eosinophil accumulation in pulmonary airways of guinea-pigs induced by exposure to an aerosol of platelet-activating factor: effect of anti-asthma drugs.血小板活化因子气雾剂暴露诱导豚鼠肺气道嗜酸性粒细胞积聚：抗哮喘药物的作用
Br J Pharmacol. 1990 Feb;99(2):267-72. doi: 10.1111/j.1476-5381.1990.tb14692.x.
6
Effect of PAF-antagonists on aeroallergen-induced bronchial eosinophilia in guinea pigs: a therapeutic approach.血小板活化因子拮抗剂对豚鼠气源性变应原诱导的支气管嗜酸性粒细胞增多的影响：一种治疗方法。
Res Commun Mol Pathol Pharmacol. 1994 Oct;86(1):75-82.
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Lipoxygenase metabolites as mediators of platelet activating factor-induced increased airways responsiveness to histamine in the guinea-pig.脂氧合酶代谢产物作为血小板活化因子诱导豚鼠气道对组胺反应性增加的介质。
Agents Actions Suppl. 1988;23:195-200. doi: 10.1007/978-3-0348-9156-1_14.
8
Role for platelet-activating factor in asthma.血小板活化因子在哮喘中的作用。
Lipids. 1991 Dec;26(12):1277-9. doi: 10.1007/BF02536547.
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Effects of selective phosphodiesterase inhibitors on platelet-activating factor- and antigen-induced airway hyperreactivity, eosinophil accumulation, and microvascular leakage in guinea pigs.选择性磷酸二酯酶抑制剂对豚鼠血小板活化因子和抗原诱导的气道高反应性、嗜酸性粒细胞聚集及微血管渗漏的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1996 Jan;353(2):200-6. doi: 10.1007/BF00168758.
10
PAF antagonism as an approach to the treatment of airway hyperreactivity.血小板活化因子拮抗剂作为治疗气道高反应性的一种方法。
Am Rev Respir Dis. 1991 Mar;143(3 Pt 2):S79-82. doi: 10.1164/ajrccm/143.3_Pt_2.S79.

引用本文的文献

1
Potassium channel openers and asthma.钾通道开放剂与哮喘
Clin Rev Allergy. 1994 Spring;12(1):109-20. doi: 10.1007/BF02815513.
2
Lung inflammation, its significance for asthma therapy.肺部炎症及其在哮喘治疗中的意义。
Agents Actions. 1989 Jan;26(1-2):31-9. doi: 10.1007/BF02126555.
3
The contribution of platelet-activating factor to allergen-induced eosinophil infiltration and bronchial hyperresponsiveness.
Lipids. 1991 Dec;26(12):1280-2. doi: 10.1007/BF02536548.