Taiana Elisa, Ronchetti Domenica, Todoerti Katia, Nobili Lucia, Tassone Pierfrancesco, Amodio Nicola, Neri Antonino
Department of Oncology and Hemato-oncology, University of Milan, 20122 Milan, Italy.
Hematology, Fondazione Cà Granda IRCCS Policlinico, 20122 Milan, Italy.
Noncoding RNA. 2020 Jul 1;6(3):26. doi: 10.3390/ncrna6030026.
Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) reported to be frequently deregulated in various types of cancers and neurodegenerative processes. NEAT1 is an indispensable structural component of paraspeckles (PSs), which are dynamic and membraneless nuclear bodies that affect different cellular functions, including stress response. Furthermore, increasing evidence supports the crucial role of NEAT1 and essential structural proteins of PSs (PSPs) in the regulation of the DNA damage repair (DDR) system. This review aims to provide an overview of the current knowledge on the involvement of NEAT1 and PSPs in DDR, which might strengthen the rationale underlying future NEAT1-based therapeutic options in tumor and neurodegenerative diseases.
核旁斑组装转录本1（NEAT1）是一种长链非编码RNA（lncRNA），据报道在各种类型的癌症和神经退行性病变过程中经常失调。NEAT1是旁斑（PSs）不可或缺的结构成分，旁斑是动态的无膜核体，影响包括应激反应在内的不同细胞功能。此外，越来越多的证据支持NEAT1和旁斑的重要结构蛋白（PSPs）在DNA损伤修复（DDR）系统调节中的关键作用。本综述旨在概述目前关于NEAT1和PSPs参与DDR的知识，这可能会加强未来基于NEAT1的肿瘤和神经退行性疾病治疗选择的理论基础。
