Lee Seungho, Cho Sung-Ran, Jeong Inchul, Park Jae Bum, Shin Mi-Yeon, Kim Sungkyoon, Kim Jin Hee
Department of Occupational & Environmental Medicine, Ajou University School of Medicine, Suwon 16499, Korea.
Department of Laboratory Medicine, Ajou University School of Medicine, Suwon 16499, Korea.
Toxics. 2020 Jul 1;8(3):47. doi: 10.3390/toxics8030047.
Mercury (Hg) has obesogenic properties. However, the associated health outcomes of population-level mercury exposure were unclear. This study investigated the relationships between blood mercury levels and obesity-related outcomes such as hyperlipidemia and elevated liver enzymes. Using the second cycle of the Korean National Environmental Health Survey ( = 6454), we performed logistic regression to examine the effects of Hg on hyperlipidemia and elevated liver enzymes. The blood mercury levels were significantly higher in the hyperlipidemia group ( = 3699, male: 4.03 μg/L, female: 2.83 μg/L) compared to the non-hyperlipidemia group ( = 2755, male: 3.48 μg/L, female: 2.69 μg/L), and high blood mercury levels were associated with an 11% higher risk of hyperlipidemia. The elevated liver enzymes group had higher mean blood mercury levels ( = 1189, male: 4.38 μg/L, female: 3.25 μg/L) than the normal group ( = 5265, male: 3.64 μg/L, female: 2.70 μg/L), and elevated blood mercury was associated with a 35% higher risk of elevated liver enzymes. Moreover, the effect was constant after adjusting for personal medications. These results indicate that mercury exposure is significantly associated with hyperlipidemia and elevated liver enzymes.
汞（Hg）具有致肥胖特性。然而，人群水平汞暴露相关的健康结果尚不清楚。本研究调查了血汞水平与高脂血症和肝酶升高之类的肥胖相关结果之间的关系。利用韩国全国环境卫生调查的第二轮数据（n = 6454），我们进行了逻辑回归以检验汞对高脂血症和肝酶升高的影响。与非高脂血症组（n = 2755，男性：3.48μg/L，女性：2.69μg/L）相比，高脂血症组（n = 3699，男性：4.03μg/L，女性：2.83μg/L）的血汞水平显著更高，且高血汞水平与高脂血症风险高11%相关。肝酶升高组的平均血汞水平（n = 1189，男性：4.38μg/L，女性：3.25μg/L）高于正常组（n = 5265，男性：3.64μg/L，女性：2.70μg/L），且血汞升高与肝酶升高风险高35%相关。此外，在调整个人用药情况后该效应依然存在。这些结果表明汞暴露与高脂血症和肝酶升高显著相关。
