Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA.
Biomolecules. 2020 Jul 1;10(7):987. doi: 10.3390/biom10070987.
Ingestion of alcohol is associated with numerous changes in human energy metabolism, especially that of plasma lipids and lipoproteins. Regular moderate alcohol consumption is associated with reduced atherosclerotic cardiovascular disease (ASCVD), an effect that has been attributed to the concurrent elevations of plasma high-density lipoprotein-cholesterol (HDL-C) concentrations. More recent evidence has accrued against the hypothesis that raising plasma HDL concentrations prevents ASCVD so that other metabolic processes associated with alcohol consumption have been considered. This review explored the roles of other metabolites induced by alcohol consumption-triglyceride-rich lipoproteins, non-esterified free fatty acids, and acetate, the terminal alcohol metabolite in athero-protection: Current evidence suggests that acetate has a key role in athero-protection but additional studies are needed.
饮酒会引起人体能量代谢的诸多变化，尤其是血浆脂质和脂蛋白的变化。有规律地适量饮酒与降低动脉粥样硬化性心血管疾病（ASCVD）的风险有关，这种作用归因于同时升高的血浆高密度脂蛋白胆固醇（HDL-C）浓度。越来越多的证据反对这样一种假说，即升高血浆 HDL 浓度可以预防 ASCVD，因此人们开始考虑与饮酒相关的其他代谢过程。这篇综述探讨了饮酒引起的其他代谢物的作用——富含甘油三酯的脂蛋白、非酯化游离脂肪酸和乙酸，后者是一种抗动脉粥样硬化的终末酒精代谢物：目前的证据表明，乙酸在抗动脉粥样硬化中起关键作用，但还需要进一步的研究。
