Matrali Sofia S H, Ghag Anita K
School of Chemical Engineering, University of Birmingham, Birmingham B15 2TT, UK.
J Funct Biomater. 2020 Jul 1;11(3):46. doi: 10.3390/jfb11030046.
Extended bone fractures or fractures coexisting with bone disorders can lead to non-unions where surgical intervention is required. Composite drug delivery systems are being used increasingly more in order to treat such defects locally. Alendronate (ALD), a bisphosphonate extensively used in clinical practice to treat conditions, such as osteoporosis, has been shown to assist bone fracture healing through its antiresorptive capacity. This study reports the development of a polymeric composite system for the in situ delivery of ALD, which possesses enhanced encapsulation efficiency (EE%) and demonstrates controlled release over a 70-day period. ALD and calcium phosphate (CaP) were incorporated within poly (lactic-co-glycolic acid) (PLGA) microspheres, giving rise to a 70% increase in EE% compared to a control system. Finally, a preliminary toxicological evaluation demonstrated a positive effect of the system on pre-osteoblastic cells over 72 h.
长骨骨折或与骨疾病并存的骨折可导致骨不连，此时需要进行手术干预。为了局部治疗此类缺损，复合药物递送系统的应用越来越广泛。阿仑膦酸盐（ALD）是一种在临床实践中广泛用于治疗骨质疏松症等病症的双膦酸盐，已显示出通过其抗吸收能力促进骨折愈合。本研究报道了一种用于原位递送ALD的聚合物复合系统的开发，该系统具有更高的包封效率（EE%），并在70天内实现控释。将ALD和磷酸钙（CaP）掺入聚（乳酸-乙醇酸）（PLGA）微球中，与对照系统相比，EE%提高了70%。最后，初步毒理学评估表明该系统在72小时内对前成骨细胞有积极作用。
