School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou, China.
CNS Neurosci Ther. 2022 Apr;28(4):510-520. doi: 10.1111/cns.13819. Epub 2022 Mar 4.
Based on the complex pathological environment of perioperative stroke, the development of targeted therapeutic strategies is important to control the development of perioperative stroke.
Recently, great progress has been made in nanotechnology, and nanodrug delivery systems have been developed for the treatment of ischemic stroke.
In this review, the pathological processes and mechanisms of ischemic stroke during perioperative stroke onset were systematically sorted. As a potential treatment strategy for perioperative stroke, the review also summarizes the multifunctional nanodelivery systems based on ischemic stroke, thus providing insight into the nanotherapeutic strategies for perioperative stroke.
基于围手术期卒中复杂的病理环境，开发靶向治疗策略对于控制围手术期卒中的发展非常重要。
最近，纳米技术取得了重大进展，已经开发出用于治疗缺血性卒中的纳米药物递送系统。
在本综述中，系统地梳理了围手术期卒中发病时缺血性卒中的病理过程和机制。作为围手术期卒中的一种潜在治疗策略，本综述还总结了基于缺血性卒中的多功能纳米递药系统，从而为围手术期卒中的纳米治疗策略提供了思路。
