Department of Internal Medicine I, Cardiology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.
Cells. 2020 Jul 2;9(7):1601. doi: 10.3390/cells9071601.
Extracellular vesicles (EVs) mediate cell-to-cell communication via the transfer of biomolecules locally and systemically between organs. It has been elucidated that the specific EV cargo load is fundamental for cellular response upon EV delivery. Therefore, revealing the specific molecular machinery that functionally regulates the precise EV cargo intracellularly is of importance in understanding the role of EVs in physiology and pathophysiology and conveying therapeutic use. The purpose of this review is to summarize recent findings on the general rules, as well as specific modulator motifs governing EV cargo loading. Finally, we address available information on potential therapeutic strategies to alter cargo loading.
细胞外囊泡 (EVs) 通过在器官之间局部和系统地传递生物分子来介导细胞间通讯。已经阐明，EV 递送来的特定 EV 货物负载对于细胞反应至关重要。因此，揭示功能上调节 EV 货物在细胞内精确装载的特定分子机制对于理解 EV 在生理和病理生理学中的作用以及传递治疗用途非常重要。本综述的目的是总结关于一般规律以及控制 EV 货物装载的特定调节剂基序的最新发现。最后，我们讨论了改变货物装载的潜在治疗策略的现有信息。
