Arnould R, Ghanem G, Debusschere P, Comunale J, Libert A, Vercammen-Grandjean A, Ewalenko P, Lejeune F
Laboratoire d'Oncologie et de Chirurgie expérimentale (LOCE), Institut Jules Bordet, Bruxelles, Belgium.
Anticancer Res. 1988 Jul-Aug;8(4):775-9.
The production of Interleukin 1 (Il1) by circulating blood monocytes and alveolar macrophages was studied in melanoma patients. There were 144 patients in the monocytes study and 5 patients in the alveolar macrophages study. The Il1 activity was tested by a bioassay and reported in units based on the integration of the area under the curve. This was shown to be preferable to the standard method, i.e. probit analysis. Results showed that there was no depression of Il1 activity in melanoma patients as compared to control (98 + 32 units, versus 100 units). There was no difference when the values were compared according to sex, age and stage of the disease. However, a significant difference was found between phototype I and phototype IV. Alveolar macrophages, in all experiments (n = 5), had a significantly lower Il1 activity than the autologous monocytes. It is concluded that we can question the relevance of Il1 production by peripheral blood monocytes to the state of the immunity of melanoma patients.
对黑色素瘤患者循环血单核细胞和肺泡巨噬细胞产生白细胞介素1（Il1）的情况进行了研究。单核细胞研究中有144名患者，肺泡巨噬细胞研究中有5名患者。Il1活性通过生物测定法进行检测，并根据曲线下面积的积分以单位报告。结果表明，与标准方法（即概率分析）相比，这种方法更可取。结果显示，与对照组（98 + 32单位，对照组为100单位）相比，黑色素瘤患者的Il1活性没有降低。根据性别、年龄和疾病阶段比较这些值时，没有差异。然而，在I型和IV型光皮肤类型之间发现了显著差异。在所有实验中（n = 5），肺泡巨噬细胞的Il1活性明显低于自体单核细胞。得出的结论是，我们可以质疑外周血单核细胞产生Il1与黑色素瘤患者免疫状态的相关性。
