Molecular Biology and Immunology Department, Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera 50#26-20, Bogotá 111321, Colombia.
School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24#63C-69, Bogotá 112111, Colombia.
Int J Mol Sci. 2020 Jul 2;21(13):4729. doi: 10.3390/ijms21134729.
Protein-protein interactions (IPP) play an essential role in practically all biological processes, including those related to microorganism invasion of their host cells. It has been found that a broad repertoire of receptor-ligand interactions takes place in the binding interphase with host cells in malaria, these being vital interactions for successful parasite invasion. Several trials have been conducted for elucidating the molecular interface of interactions between some and antigens with receptors on erythrocytes and/or reticulocytes. Structural information concerning these complexes is available; however, deeper analysis is required for correlating structural, functional (binding, invasion, and inhibition), and polymorphism data for elucidating new interaction hotspots to which malaria control methods can be directed. This review describes and discusses recent structural and functional details regarding three relevant interactions during erythrocyte invasion: Duffy-binding protein 1 (DBP1)-Duffy antigen receptor for chemokines (DARC); reticulocyte-binding protein homolog 5 (Rh5)-basigin, and erythrocyte binding antigen 175 (EBA175)-glycophorin A (GPA).
蛋白质-蛋白质相互作用（IPP）在几乎所有的生物过程中都起着至关重要的作用，包括与微生物入侵宿主细胞有关的过程。已经发现，在疟疾与宿主细胞的结合相中发生了广泛的受体-配体相互作用，这些相互作用对于寄生虫成功入侵至关重要。已经进行了一些试验来阐明一些 和 抗原与红细胞和/或网织红细胞上受体之间相互作用的分子界面。这些复合物的结构信息是可用的；然而，需要更深入的分析来关联结构、功能（结合、入侵和抑制）以及多态性数据，以阐明新的相互作用热点，从而可以针对这些热点制定疟疾控制方法。本综述描述和讨论了红细胞入侵过程中三个相关相互作用的最新结构和功能细节：Duffy 结合蛋白 1（DBP1）-趋化因子 Duffy 抗原受体（DARC）；网织红细胞结合蛋白同源物 5（Rh5）-basigin 和红细胞结合抗原 175（EBA175）-糖蛋白 A（GPA）。
