• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

重组人白细胞介素-1β对兔关节软骨细胞的影响。刺激类前列腺素释放并抑制细胞生长。

Effects of recombinant human interleukin-1 beta on rabbit articular chondrocytes. Stimulation of prostanoid release and inhibition of cell growth.

作者信息

Chin J E, Lin Y A

机构信息

Medical Products Department, E. I. du Pont de Nemours and Company, Glenolden, Pennsylvania.

出版信息

Arthritis Rheum. 1988 Oct;31(10):1290-6. doi: 10.1002/art.1780311011.

DOI:10.1002/art.1780311011
PMID:3263134
Abstract

Using an in vitro model, we characterized the production of prostaglandin E2, 6-keto-prostaglandin F1 alpha, and thromboxane B2 by normal rabbit articular chondrocytes stimulated by interleukin-1 beta. The prostanoids were produced in a dose- and time-dependent manner, which was sensitive to actinomycin D and cycloheximide. Interleukin-1 also had a pronounced, but reversible, cytostatic effect on chondrocytes, which was not attributable to prostanoid or polyamine synthesis.

摘要

利用体外模型，我们对白细胞介素-1β刺激的正常兔关节软骨细胞产生前列腺素E2、6-酮-前列腺素F1α和血栓素B2的情况进行了表征。类前列腺素的产生呈剂量和时间依赖性，且对放线菌素D和环己酰亚胺敏感。白细胞介素-1对软骨细胞也有显著但可逆的细胞生长抑制作用，这并非由类前列腺素或多胺合成所致。

相似文献

1
Effects of recombinant human interleukin-1 beta on rabbit articular chondrocytes. Stimulation of prostanoid release and inhibition of cell growth.重组人白细胞介素-1β对兔关节软骨细胞的影响。刺激类前列腺素释放并抑制细胞生长。
Arthritis Rheum. 1988 Oct;31(10):1290-6. doi: 10.1002/art.1780311011.
2
In vitro effects of hyaluronan on prostaglandin E2 induction by interleukin-1 in rabbit articular chondrocytes.透明质酸对白细胞介素-1诱导兔关节软骨细胞产生前列腺素E2的体外作用。
Agents Actions. 1993 Jan;38(1-2):122-5. doi: 10.1007/BF02027223.
3
Interactions between interleukin-1 and basic fibroblast growth factor on articular chondrocytes. Effects on cell growth, prostanoid production, and receptor modulation.白细胞介素-1与碱性成纤维细胞生长因子对关节软骨细胞的相互作用。对细胞生长、前列腺素生成及受体调节的影响。
Arthritis Rheum. 1991 Mar;34(3):314-24. doi: 10.1002/art.1780340309.
4
Prostanoid release of cultured liver sinusoidal endothelial cells in response to endotoxin and tumor necrosis factor. Comparison with umbilical vein endothelial cells.培养的肝窦内皮细胞对内毒素和肿瘤坏死因子的类前列腺素释放。与脐静脉内皮细胞的比较。
J Hepatol. 1990 Nov;11(3):359-66. doi: 10.1016/0168-8278(90)90222-d.
5
Stimulation of human chondrocyte prostaglandin E2 production by recombinant human interleukin-1 and tumour necrosis factor.
Biochim Biophys Acta. 1990 Mar 9;1051(3):310-8. doi: 10.1016/0167-4889(90)90140-9.
6
Anti-inflammatory drugs, prostanoid and proteoglycan production by cultured bovine articular chondrocytes.培养的牛关节软骨细胞产生的抗炎药物、前列腺素和蛋白聚糖
Prostaglandins. 1984 Sep;28(3):417-34. doi: 10.1016/0090-6980(84)90026-1.
7
Correlation of the biosynthesis of prostaglandin and cyclic AMP in monolayer cultures of rabbit articular chondrocytes.兔关节软骨细胞单层培养中前列腺素生物合成与环磷酸腺苷的相关性
Biochim Biophys Acta. 1982 Mar 15;715(1):70-9. doi: 10.1016/0304-4165(82)90051-4.
8
Platelet-derived growth factor potentiates cellular responses of articular chondrocytes to interleukin-1.
Arthritis Rheum. 1991 Jun;34(6):697-706. doi: 10.1002/art.1780340610.
9
Independent induction of interleukin 6 and prostaglandin E2 by interleukin 1 in human articular chondrocytes.
Biochem Biophys Res Commun. 1990 Feb 14;166(3):1163-70. doi: 10.1016/0006-291x(90)90988-y.
10
Prostaglandin biosynthesis by lapine articular chondrocytes in culture.培养的兔关节软骨细胞中前列腺素的生物合成
Biochim Biophys Acta. 1981 Feb 23;663(2):480-90. doi: 10.1016/0005-2760(81)90176-4.

引用本文的文献

1
An aggrecan-degrading activity associated with chondrocyte membranes.一种与软骨细胞膜相关的聚集蛋白聚糖降解活性。
Biochem J. 1998 Nov 15;336 ( Pt 1)(Pt 1):207-12. doi: 10.1042/bj3360207.
2
Effects of three avocado/soybean unsaponifiable mixtures on metalloproteinases, cytokines and prostaglandin E2 production by human articular chondrocytes.三种鳄梨/大豆不皂化物混合物对人关节软骨细胞中金属蛋白酶、细胞因子及前列腺素E2生成的影响
Clin Rheumatol. 1998;17(1):31-9. doi: 10.1007/BF01450955.
3
Effects of the cytokines on the proliferation of and collagen synthesis by human cataract lens epithelial cells.
细胞因子对人白内障晶状体上皮细胞增殖及胶原合成的影响。
Br J Ophthalmol. 1996 Jan;80(1):63-8. doi: 10.1136/bjo.80.1.63.
4
Chondrotoxicity of quinolones in vivo and in vitro.
Arch Toxicol. 1993;67(6):411-5. doi: 10.1007/BF01977402.
5
Cytokine enhancement of monocyte/synovial cell attachment to the surface of cartilage: a possible trigger of pannus formation in arthritis.细胞因子增强单核细胞/滑膜细胞与软骨表面的附着：关节炎中血管翳形成的可能触发因素。
Rheumatol Int. 1991;11(1):31-6. doi: 10.1007/BF00290248.
6
Effects of recombinant human IL-1 beta on production of prostaglandin E2, leukotriene B4, NAG, and superoxide by human synovial cells and chondrocytes.重组人白细胞介素-1β对人滑膜细胞和软骨细胞产生前列腺素E2、白三烯B4、N-乙酰-β-D-氨基葡萄糖苷酶和超氧化物的影响。
Inflammation. 1991 Apr;15(2):145-57. doi: 10.1007/BF00917509.
7
Disease severity in rheumatoid arthritis: relationships of plasma tumor necrosis factor-alpha, soluble interleukin 2-receptor, soluble CD4/CD8 ratio, neopterin, and fibrin D-dimer to traditional severity and functional measures.类风湿关节炎的疾病严重程度：血浆肿瘤坏死因子-α、可溶性白细胞介素2受体、可溶性CD4/CD8比值、新蝶呤及纤维蛋白D - 二聚体与传统严重程度及功能指标的关系
J Clin Immunol. 1992 Sep;12(5):353-61. doi: 10.1007/BF00920793.
8
Hyperphospholipasemia A2 in human volunteers challenged with intravenous endotoxin.静脉注射内毒素的人类志愿者中的高磷脂酶A2血症
Inflammation. 1992 Oct;16(5):561-70. doi: 10.1007/BF00918980.