透明质酸对白细胞介素-1诱导兔关节软骨细胞产生前列腺素E2的体外作用。
In vitro effects of hyaluronan on prostaglandin E2 induction by interleukin-1 in rabbit articular chondrocytes.
作者信息
Akatsuka M, Yamamoto Y, Tobetto K, Yasui T, Ando T
机构信息
Division of Biochemical Pharmacology, Maruho Co., Ltd., Osaka, Japan.
出版信息
Agents Actions. 1993 Jan;38(1-2):122-5. doi: 10.1007/BF02027223.
Effects of hyaluronan (HA) on the prostaglandin E2 (PGE2) production induced by recombinant human interleukin-1 beta (rhIL-1 beta) in rabbit articular chondrocytes were studied in vitro. The rhIL-1 beta-induced PGE2 production was dose-dependently inhibited by HA. HA with the highest molecular weight (M(r) = 2.0 x 10(6)) exhibited an inhibitory effect that was statistically more significant than the same polymer of lower molecular weights (M(r) = 1.0 x 10(6), 0.5 x 10(6)). This effect was observed in both young and adult rabbit articular chondrocytes. Since PGE2 has been implicated as a mediator of inflammatory joint diseases, our observations suggest that HA may elicit an anti-inflammatory effect by inhibiting PGE2 production.
在体外研究了透明质酸（HA）对重组人白细胞介素-1β（rhIL-1β）诱导兔关节软骨细胞产生前列腺素E2（PGE2）的影响。HA对rhIL-1β诱导的PGE2产生具有剂量依赖性抑制作用。分子量最高（M(r)=2.0×10(6)）的HA表现出的抑制作用在统计学上比相同聚合物的较低分子量（M(r)=1.0×10(6)，0.5×10(6)）更显著。在幼年和成年兔关节软骨细胞中均观察到这种效应。由于PGE2被认为是炎症性关节疾病的介质，我们的观察结果表明，HA可能通过抑制PGE2的产生而发挥抗炎作用。
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