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Age and sex differences in soluble ACE2 may give insights for COVID-19.可溶性血管紧张素转换酶2的年龄和性别差异可能为新冠病毒疾病提供见解。
Crit Care. 2020 May 14;24(1):221. doi: 10.1186/s13054-020-02942-2.
2
Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy.意大利伦巴第地区 1591 名 ICU 收治的 SARS-CoV-2 感染患者的基线特征和结局。
JAMA. 2020 Apr 28;323(16):1574-1581. doi: 10.1001/jama.2020.5394.
3
Angiotensin Converting Enzyme 2: A Double-Edged Sword.血管紧张素转换酶2：一把双刃剑。
Circulation. 2020 Aug 4;142(5):426-428. doi: 10.1161/CIRCULATIONAHA.120.047049. Epub 2020 Mar 26.
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Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2.全长人血管紧张素转化酶 2 识别 SARS-CoV-2 的结构基础。
Science. 2020 Mar 27;367(6485):1444-1448. doi: 10.1126/science.abb2762. Epub 2020 Mar 4.
5
Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS.血管紧张素 II 诱导心肌 ACE2 的蛋白水解切割是由 TACE/ADAM-17 介导的：RAS 中的正反馈机制。
J Mol Cell Cardiol. 2014 Jan;66:167-76. doi: 10.1016/j.yjmcc.2013.11.017. Epub 2013 Dec 9.
6
Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2.血管紧张素转换酶抑制和血管紧张素II受体阻滞剂对心脏血管紧张素转换酶2的影响。
Circulation. 2005 May 24;111(20):2605-10. doi: 10.1161/CIRCULATIONAHA.104.510461. Epub 2005 May 16.

Clarifying the controversial risk-benefit profile of soluble ACE2 in COVID-19.

作者信息

Leow Melvin Khee Shing

机构信息

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Republic of Singapore.

Duke-NUS Medical School, Singapore, Republic of Singapore.

出版信息

Crit Care. 2020 Jul 6;24(1):396. doi: 10.1186/s13054-020-03097-w.

DOI:10.1186/s13054-020-03097-w
PMID:32631373
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7338146/
Abstract
摘要