Department of Medicine, McGill University, 1001 Decarie Boulevard, Suite D05-2212, Montreal, Quebec H4A 3J1, Canada.
Department of Pathology and Laboratory Medicine, University of British Columbia, Room G227 - 2211 Wesbrook Mall, Vancouver, British Columbia V6T 2B5, Canada.
Rheum Dis Clin North Am. 2020 Aug;46(3):533-550. doi: 10.1016/j.rdc.2020.05.005. Epub 2020 Jun 10.
Systemic lupus erythematosus is associated with a small overall increased cancer risk compared with the general population. This risk includes a 4-fold increased risk of non-Hodgkin lymphoma, but a decreased risk of other cancers (such as breast cancer). The pathophysiology underlying the increased risk of hematologic cancer is not fully understood, but many potential mechanisms have been proposed, including dysfunction of the tumor necrosis factor and other pathways. A decreased risk of breast, ovarian, and endometrial cancer might be driven by hormonal factors or lupus-related antibodies, but these links have not been proved.
系统性红斑狼疮与一般人群相比，整体癌症风险略有增加。这种风险包括非霍奇金淋巴瘤的风险增加 4 倍，但其他癌症（如乳腺癌）的风险降低。导致血液系统癌症风险增加的病理生理学机制尚未完全阐明，但已经提出了许多潜在的机制，包括肿瘤坏死因子和其他途径的功能障碍。乳腺癌、卵巢癌和子宫内膜癌风险降低可能是由激素因素或狼疮相关抗体驱动的，但这些关联尚未得到证实。
