Wang Ling, Zhang Qin, Shi Nan, Wang Jiaxi, Song Shuang, Yang Huadi, Chen Xingbei
Department of TCM Gynecology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.
Department of Gynecology and Obstetrics, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China.
Front Oncol. 2024 Feb 21;14:1322598. doi: 10.3389/fonc.2024.1322598. eCollection 2024.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple systems. Patients with SLE are prone to a variety of malignancies, especially neoplasms of the female reproductive tract. Synchronous tumors, considered to involve multiple sites, are rare in the female reproductive tract. There are hardly any reports of SLE with synchronous reproductive tract tumors.
We report the occurrence of two to three reproductive tract tumors in two women with SLE. A 52-year-old woman was diagnosed with vulvar cancer and cervical cancer. Another woman, aged 67, was diagnosed with concurrent vulvar cancer, vaginal cancer, and cervical cancer and also presented with a suspected lung cancer.
The presence of synchronous tumors of the reproductive tract in patients with SLE is uncommon and can be easily disregarded. It is crucial to highlight that SLE patients with multiple primary malignancies exhibit notable late-stage presentation at the time of diagnosis, inadequate disease-free survival, poor overall survival, rapid progression rates, and mortality. Consequently, greater awareness must be raised regarding synchronous reproductive tract tumors in patients with SLE. Regular comprehensive cancer screening and management should be implemented for individuals diagnosed with SLE.
系统性红斑狼疮（SLE）是一种影响多个系统的慢性自身免疫性疾病。SLE患者易患多种恶性肿瘤，尤其是女性生殖道肿瘤。同步肿瘤被认为累及多个部位，在女性生殖道中较为罕见。几乎没有关于SLE合并同步生殖道肿瘤的报道。
我们报告了两名SLE女性患者发生两到三种生殖道肿瘤的情况。一名52岁女性被诊断为外阴癌和宫颈癌。另一名67岁女性被诊断为同时患有外阴癌、阴道癌和宫颈癌，还疑似患有肺癌。
SLE患者出现生殖道同步肿瘤并不常见，且容易被忽视。需要强调的是，患有多种原发性恶性肿瘤的SLE患者在诊断时表现出明显的晚期症状，无病生存期不足，总生存期较差，进展速度快且死亡率高。因此，必须提高对SLE患者同步生殖道肿瘤的认识。对于诊断为SLE的个体，应定期进行全面的癌症筛查和管理。
