Gibb W R, Costall B, Domeney A M, Kelly M E, Naylor R J
National Hospital for Nervous Diseases, London, U.K.
Brain Res. 1988 Oct 4;461(2):361-6. doi: 10.1016/0006-8993(88)90268-5.
Bilateral infusion of MPTP into the substantia nigra, ventral tegmental area or putamen of the rat brain provoked accumulation of leucocytes, but the periphery of nigral lesions showed no significant nerve cell loss. Tyrosine hydroxylase labelling of dopaminergic perikarya showed a normal staining pattern. In contrast, MPP+ was more destructive. After one day there was local degeneration of neuronal and glial elements. After one month there was tissue necrosis and central cavitation, but, like MPTP, there was no evidence of selective nigral cell loss. Striatal injection of MPP+ also failed to produce retrograde nigral damage. It is concluded that the toxicity of MPP+ applied directly to the dopamine system is a consequence of a severe non-selective necrotic lesion.
向大鼠脑黑质、腹侧被盖区或壳核双侧注入1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）会引发白细胞聚集，但黑质损伤周边未出现明显的神经细胞丢失。多巴胺能神经元胞体的酪氨酸羟化酶标记显示出正常的染色模式。相比之下，1-甲基-4-苯基吡啶离子（MPP+）的破坏性更强。一天后，神经元和神经胶质成分出现局部变性。一个月后出现组织坏死和中央空洞形成，但与MPTP一样，没有选择性黑质细胞丢失的证据。纹状体内注射MPP+也未能产生逆行性黑质损伤。得出的结论是，直接应用于多巴胺系统的MPP+的毒性是严重非选择性坏死性病变的结果。
