Neibart Shane S, Manne Sharon L, Jabbour Salma K
Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, United States.
Department of Medicine, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, United States.
Curr Colorectal Cancer Rep. 2020 Feb;16(1):1-10. doi: 10.1007/s11888-019-00448-w. Epub 2020 Jan 16.
With advances in radiation therapy (RT) techniques for rectal and anal cancers allowing for the modulation of critical normal tissues, there has been an increased emphasis on improving the quality of life (QOL) of cancer survivors. Herein, we review the literature to examine the impact of RT on QOL and patient reported outcomes (PROs) to better inform providers about the challenges of survivorship.
Large systematic reviews, recent studies and long-term follow-up of pivotal clinical trials have shown that RT impacts QOL, particularly fecal continence and sexual function. Modern preoperative RT techniques allow for decreased dose to organs-at-risk will likely improve QOL.
RT, though critical in the treatment of rectal and anal cancer, has a profound impact on QOL for some patients. Recent studies have included PROs and validated QOL metrics to better inform providers and patients.
随着直肠癌和肛管癌放射治疗（RT）技术的进步，能够对关键正常组织进行调节，人们越来越重视提高癌症幸存者的生活质量（QOL）。在此，我们回顾文献，以研究放疗对生活质量和患者报告结局（PROs）的影响，从而更好地让医疗服务提供者了解生存的挑战。
大型系统综述、近期研究以及关键临床试验的长期随访表明，放疗会影响生活质量，尤其是大便失禁和性功能。现代术前放疗技术可降低对危及器官的剂量，可能会改善生活质量。
放疗虽然在直肠癌和肛管癌的治疗中至关重要，但对一些患者的生活质量有深远影响。近期研究纳入了患者报告结局和经过验证的生活质量指标，以便更好地为医疗服务提供者和患者提供信息。
