Agosti E, Radillo O, Narchi G, Lepore L, De Manzini A, Vidoni L, Gazzola G, Tedesco F
Istituto di Clinica Pediatrica, Università di Trieste.
Clin Exp Rheumatol. 1988 Jul-Sep;6(3):319-24.
Seven pediatric patients with monoarticular arthritis, three of whom had a recent onset form and the remaining four a disease of longer duration, were examined for possible modifications of their immunological parameters. The diagnosis of JRA was made on all these patients according to the ARA criteria after a follow-up of at least two years. Humoral and cellular abnormalities of the immune system were searched for in peripheral blood, synovial fluid and synovial membrane. No evidence for complement consumption and for increased levels of immune-complexes was found in the sera and in the synovial fluids of these patients, who were all seronegative. Some patients had antinuclear antibodies in their sera and synovial fluids. With regard to the lymphocyte distribution, whereas only some patients had an increased number of circulating B cells, the majority had a decreased CD4+/CD8+ ratio in the synovial fluid compared to the ratio found in the peripheral blood. A massive infiltration of CD4+ cells and macrophages and the presence of a substantial number of OKT9+ cells was found in the synovial membranes.
七名单关节关节炎患儿接受了检查，以确定其免疫参数是否可能发生改变。其中三名患儿为近期发病型，其余四名患儿病程较长。所有这些患儿均根据美国风湿病学会（ARA）标准进行了至少两年的随访后确诊为幼年类风湿关节炎（JRA）。在这些患儿的外周血、滑液和滑膜中寻找免疫系统的体液和细胞异常。在这些血清学阴性的患儿的血清和滑液中，未发现补体消耗及免疫复合物水平升高的证据。部分患儿的血清和滑液中存在抗核抗体。关于淋巴细胞分布，只有部分患儿循环B细胞数量增加，而与外周血中的比例相比，大多数患儿滑液中的CD4+/CD8+比值降低。在滑膜中发现了大量CD4+细胞和巨噬细胞浸润以及大量OKT9+细胞。
