Sakkas L I, Platsoucas C D
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pa., USA.
Immunol Res. 1995;14(3):218-36. doi: 10.1007/BF02918218.
Juvenile rheumatoid arthritis (JRA) is defined as chronic arthritis of unknown etiology appearing in patients less than 16 years of age. The disease is heterogeneous and is classified as pauciarticular, polyarticular, or systemic-onset disease. A few lines of evidence suggest that T cells are involved in the pathogenesis of the disease. T cells infiltrating the synovial membrane bear markers of activation and produce cytokines. The association of particular subtypes of JRA with certain HLA class II alleles provides strong evidence in favor of T cell involvement through an HLA-peptide-T cell receptor complex. Limited data from a few patients with JRA on T cell receptor transcripts from synovial membrane or synovial fluid cells point towards oligoclonality. This further supports the concept that T cells infiltrating the synovial membrane or extravasating into synovial fluid in patients with JRA reflect antigen-driven T cell proliferation.
青少年类风湿性关节炎（JRA）被定义为病因不明的慢性关节炎，出现在16岁以下的患者中。该疾病具有异质性，分为少关节型、多关节型或全身发病型疾病。一些证据表明T细胞参与了该疾病的发病机制。浸润滑膜的T细胞带有活化标记并产生细胞因子。JRA的特定亚型与某些HLA II类等位基因的关联提供了有力证据，支持通过HLA-肽-T细胞受体复合物参与T细胞。来自少数JRA患者关于滑膜或滑液细胞T细胞受体转录本的有限数据指向寡克隆性。这进一步支持了这样的概念，即浸润JRA患者滑膜或渗入滑液的T细胞反映了抗原驱动的T细胞增殖。
