青少年类风湿性关节炎患者血浆中C3裂解产物的免疫学及临床关联

The immunologic and clinical associations of the split products of C3 in plasma in juvenile rheumatoid arthritis.

作者信息

Miller J J, Hsu Y P, Moss R, Kelomaa-Sulonen K, Osborne C L, Olds-Arroyo L

出版信息

Arthritis Rheum. 1979 May;22(5):502-7. doi: 10.1002/art.1780220510.

DOI:10.1002/art.1780220510

Abstract

A qualitative counterimmunoelectrophoretic assay for the complement activation products C3c and C3d was used to study plasma from children with juvenile rheumatoid arthritis (JRA) and other rheumatic diseases. Positive tests for C3c,d were found in all patients with active systemic lupus erythematosus (SLE), 7 of 10 patients with active systemic JRA, 16 of 29 with active polyarticular JRA, 7 of 20 with active pauciarticular JRA, and in only 2 of 20 with inactive joint disease. The incidence of positive assays for C3c,d in JRA was increased in the presence of positive latex fixation tests, antinuclear antibody tests, or elevated values for antiglobulins as determined by affinity chromatography, but these associations were not statistically significant. Three joint fluids from children with pauciarticular JRA were negative for C3c,d. These studies show that the subgroups of JRA defined by clinical criteria are heterogeneous by current laboratory parameters and that evidence implicating antigen-antibody complexes in the pathogenesis of JRA is lacking in many patients.

摘要

采用一种针对补体激活产物C3c和C3d的定性对流免疫电泳分析法，对青少年类风湿性关节炎（JRA）患儿及其他风湿性疾病患儿的血浆进行研究。在所有活动性系统性红斑狼疮（SLE）患者、10例活动性全身型JRA患者中的7例、29例活动性多关节型JRA患者中的16例、20例活动性少关节型JRA患者中的7例以及20例非活动性关节疾病患者中的2例中，均检测到C3c、d呈阳性。当乳胶凝集试验、抗核抗体试验呈阳性，或通过亲和层析法测定的抗球蛋白值升高时，JRA患者中C3c、d检测呈阳性的发生率会增加，但这些关联无统计学意义。3例少关节型JRA患儿的关节液C3c、d检测为阴性。这些研究表明，根据临床标准定义的JRA亚组，按照目前的实验室参数来看具有异质性，而且在许多患者中缺乏抗原 - 抗体复合物参与JRA发病机制的证据。