Instituto Tecnológico de Educación Superior, Zapopan, 45138, Jalisco, Mexico.
CNR-Nanoscience Institute-S3, Via Campi 213/A, 41125, Modena, Italy.
Eur Biophys J. 2020 Jul;49(5):401-408. doi: 10.1007/s00249-020-01445-w. Epub 2020 Jul 6.
The lipid bilayer is the basis of the structure and function of the cell membrane. The study of the molecular phenomena that affect biological membranes has a great impact on the understanding of cellular physiology. To understand these phenomena, it has become increasingly necessary to develop simple synthetic models that allow the most basic details of such processes to be reproduced. In this short communication, we took advantage of the properties of two well-established lipid model systems, GUVs and SLBs, with compositions mimicking the cell membrane present in mammals and bacteria, to study the thermotropic phase behavior of lipids as well as the effect of daptomycin, a cyclic lipopeptide used as an antibiotic. The study of mechanical and thermodynamical properties of these model systems could contribute to establish a theoretical framework to develop more efficient strategies for biological control.
脂质双层是细胞膜结构和功能的基础。研究影响生物膜的分子现象对理解细胞生理学有很大的影响。为了理解这些现象，开发简单的合成模型来再现这些过程的最基本细节变得越来越必要。在这篇简短的交流中，我们利用了两种成熟的脂质模型系统，GUV 和 SLB 的特性，它们的组成模拟了哺乳动物和细菌中存在的细胞膜，以研究脂质的热相变行为以及达托霉素的影响，达托霉素是一种用作抗生素的环状脂肽。这些模型系统的力学和热力学性质的研究有助于建立一个理论框架，以开发更有效的生物控制策略。
