Department of Sport Rehabilitation, Shanghai University of Sport, 188 Hengren Road, Shanghai, 200438, China.
Neurotherapeutics. 2020 Jul;17(3):917-931. doi: 10.1007/s13311-020-00881-y.
Neuropathic pain (NP) is directly caused by an injury or disease of the somatosensory nervous system. It is a serious type of chronic pain that is a burden to the economy and public health. Although recent studies have improved our understanding of NP, its pathogenesis has not been fully elucidated. Noncoding RNAs, including lncRNAs, circRNAs, and miRNAs, are involved in the pathological development of NP through many mechanisms. In addition, extensive evidence suggests that novel regulatory mechanisms among lncRNAs/circRNAs, miRNAs, and mRNAs play a crucial role in the pathophysiological process of NP. In this review, we comprehensively summarize the regulatory relationship among lncRNAs/circRNAs, miRNAs, and mRNAs and emphasize the important role of the lncRNA/circRNA-miRNA-mRNA axis in NP.
神经病理性疼痛（NP）是由躯体感觉神经系统的损伤或疾病直接引起的。它是一种严重的慢性疼痛，给经济和公共卫生带来负担。尽管最近的研究提高了我们对 NP 的认识，但它的发病机制尚未完全阐明。非编码 RNA，包括长链非编码 RNA（lncRNA）、环状 RNA（circRNA）和 microRNA（miRNA），通过多种机制参与 NP 的病理发展。此外，大量证据表明，lncRNA/circRNA、miRNA 和 mRNA 之间的新型调控机制在 NP 的病理生理过程中起着至关重要的作用。在这篇综述中，我们全面总结了 lncRNA/circRNA、miRNA 和 mRNA 之间的调控关系，并强调了 lncRNA/circRNA-miRNA-mRNA 轴在 NP 中的重要作用。
