Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China.
The Second School of Clinical Medical, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Neurosci Biobehav Rev. 2022 Jan;132:968-975. doi: 10.1016/j.neubiorev.2021.10.048. Epub 2021 Nov 2.
Neuropathic pain (NP) results from a lesion or disease of the nervous system and accompanied by chronic pain, leading a serious public health issue and economic burden. In terms of the NP mechanisms remaining poorly understood, circular RNAs (circRNAs), owing to their high stability and evolutionary conservation, are expected to be used as potential therapeutic targets or diagnostic biomarkers. In this review, we concisely discuss the characteristics and biological functions of circRNAs. As emerging evidence we reviewed, deregulation of circRNAs (e.g., circ-Filip1l, circHIPK3, ciRS-7, circRNA.2837, circ-Ankib1 and circAnks1a) were involved in NP development. It suggested that specific circRNAs modulated through sponging their target miRNAs and thus regulated the homologous downstream mRNAs and proteins in neuropathic pain. These findings provide a theoretical basis for circRNAs use as biomarkers and therapeutic targets in neuropathic pain.
神经病理性疼痛（NP）是由神经系统的损伤或疾病引起的，并伴有慢性疼痛，是一个严重的公共卫生问题和经济负担。由于 NP 的发病机制仍不清楚，环状 RNA（circRNA）由于其高度稳定性和进化保守性，有望被用作潜在的治疗靶点或诊断生物标志物。在这篇综述中，我们简要讨论了 circRNA 的特征和生物学功能。我们综述了新兴的证据表明，circRNA 的失调（例如，circ-Filip1l、circHIPK3、ciRS-7、circRNA.2837、circ-Ankib1 和 circAnks1a）参与了 NP 的发展。这表明，特定的 circRNA 通过海绵吸附其靶 miRNA 进行调节，从而调节神经病理性疼痛中的同源下游 mRNAs 和蛋白质。这些发现为 circRNA 作为神经病理性疼痛的生物标志物和治疗靶点的应用提供了理论依据。
