Ding Mengli, Miao Zhaohua, Zhang Fan, Liu Jie, Shuai Xintao, Zha Zhengbao, Cao Zhong
School of Biomedical Engineering, Sun Yat-sen University, Guangzhou, 510006, PR China.
Biomater Sci. 2020 Aug 7;8(15):4157-4165. doi: 10.1039/d0bm00625d. Epub 2020 Jul 7.
Catalytic nanomedicine with high oxygen-generation efficiency may find applications in alleviating tumor hypoxia and improving the efficiency of photodynamic therapy (PDT). In this study, a catalytic nanosystem (Ce6-Rh@MPDA) was developed using mesoporous polydopamine nanoparticles (MPDA) to encapsulate catalase-like rhodium nanoparticles (Rh NPs) and photosensitizer chlorine6 (Ce6) for photoacoustic/fluorescence dual imaging-guided tumor therapy. The Rh NPs can catalyze the production of O from tumor-enriched HOin situ, in which the mesoporous structure of MPDA plays an important role via improving the catalytic efficiency of Rh NPs. Moreover, the hyperthermia generated by both MPDA and Rh NPs under laser irradiation accelerates the O generation to promote the PDT. The Ce6-Rh@MPDA nanoparticles described herein represent a multifunctional metal-based catalytic nanomedicine which not only alleviates tumor hypoxia but also enables a synergistic antitumor treatment using PTT and PDT.
具有高氧生成效率的催化纳米药物可能在缓解肿瘤缺氧和提高光动力疗法（PDT）效率方面找到应用。在本研究中，开发了一种催化纳米系统（Ce6-Rh@MPDA），使用介孔聚多巴胺纳米颗粒（MPDA）包裹类过氧化氢酶铑纳米颗粒（Rh NPs）和光敏剂氯6（Ce6），用于光声/荧光双成像引导的肿瘤治疗。Rh NPs可以原位催化肿瘤富集的H2O2产生O2，其中MPDA的介孔结构通过提高Rh NPs的催化效率发挥重要作用。此外，MPDA和Rh NPs在激光照射下产生的热疗加速了O2的生成，以促进PDT。本文所述的Ce6-Rh@MPDA纳米颗粒代表了一种多功能金属基催化纳米药物，它不仅能缓解肿瘤缺氧，还能使用光热疗法（PTT）和光动力疗法（PDT）进行协同抗肿瘤治疗。
