脑出血患者感染新型冠状病毒2的病理生理学
Pathophysiology of SARS-CoV-2 infection in patients with intracerebral hemorrhage.
作者信息
Dong Sisi, Liu Peipei, Luo Yuhan, Cui Ying, Song Lilong, Chen Yingzhu
机构信息
The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China.
Department of Neurology, Clinical Medical College, Yangzhou University, Yangzhou 225001, Jiangsu, China.
出版信息
Aging (Albany NY). 2020 Jul 7;12(13):13791-13802. doi: 10.18632/aging.103511.
Abstract
Intracerebral hemorrhage (ICH) is associated with old age and underlying conditions such as hypertension and diabetes. ICH patients are vulnerable to SARS-CoV-2 infection and develop serious complications as a result of infection. The pathophysiology of ICH patients with SARS-CoV-2 infection includes viral invasion, dysfunction of the ACE2-Ang (1-7)-MasR and ACE-Ang II-ATR axes, overactive immune response, cytokine storm, and excessive oxidative stress. These patients have high morbidity and mortality due to hyaline membrane formation, respiratory failure, neurologic deficits, and multiple organ failure.
摘要
脑出血（ICH）与老年及高血压、糖尿病等基础疾病相关。脑出血患者易感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2），并因感染而出现严重并发症。感染SARS-CoV-2的脑出血患者的病理生理学包括病毒侵袭、血管紧张素转换酶2-血管紧张素（1-7）-Mas受体（ACE2-Ang (1-7)-MasR）和血管紧张素转换酶-血管紧张素II-血管紧张素II受体1（ACE-Ang II-ATR）轴功能障碍、免疫反应过度活跃、细胞因子风暴和过度氧化应激。这些患者由于透明膜形成、呼吸衰竭、神经功能缺损和多器官功能衰竭而具有高发病率和死亡率。
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