Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center, Tufts University, Boston, Massachusetts.
Department of Health Sciences and Kinesiology, Biodynamics and Human Performance Center, Georgia Southern University (Armstrong Campus), Savannah, Georgia.
J Am Geriatr Soc. 2020 Jul;68(7):1445-1453. doi: 10.1111/jgs.16525. Epub 2020 Jul 7.
The Sarcopenia Definitions and Outcomes Consortium (SDOC) is a collaborative initiative seeking to develop and evaluate cut-points for low muscle strength and lean mass that predict an increased risk for slowness (usual walking speed <.8 m/s) among older adults.
The goal of the present study was to provide clinicians and researchers with an understanding of the diagnostic implications of using SDOC variables and cut-points in mobility-limited older adults. Using data from older individuals with specific conditions that render them at increased risk for mobility limitation, we evaluated the performance characteristics (ie, sensitivity and specificity) of five putative sarcopenia parameters and then compared these values with previously recommended diagnostic criteria for sarcopenia.
Retrospective analysis of six randomized controlled trials enriched in persons at risk for mobility limitation.
National and international geriatric clinical research centers.
A total of 925 mobility-limited older adults (≥55 years of age; 58% women) were included in the analysis.
The prevalence of low muscle strength and lean mass were assessed using five candidate metrics discriminative of slowness. Analyses of sensitivity and specificity were used to compare muscle weakness criteria with published diagnostics for sarcopenia.
Odds ratios (ORs) supported maximal grip strength (Grip max <35.5 and 20.0 in men and women, respectively) as the most discriminative of slowness in both men and women (OR = 3.66 and 3.53, respectively). More men (58%) than women (30%) fell below sex-specific maximal grip cut-points. When applying previously recommended sarcopenia component definitions in our population, we found that fewer individuals met those criteria (range = 6%-32%).
A greater number of individuals fall below SDOC Grip max cut-points compared with previous recommendations. Clinicians and researchers working with older adults may consider these thresholds as an inclusive means to identify candidates for low-risk lifestyle promyogenic and function-promoting therapies. J Am Geriatr Soc 68:1445-1453, 2020.
肌肉减少症定义和结局联合会（SDOC）是一个合作性倡议，旨在开发和评估用于预测老年人行动缓慢（通常步行速度<0.8m/s）风险增加的低肌肉力量和瘦体重切点。
本研究的目的是让临床医生和研究人员了解使用 SDOC 变量和切点对行动受限的老年人进行诊断的意义。利用存在增加行动受限风险的特定疾病的老年人数据，我们评估了五种潜在的肌肉减少症参数的性能特征（即敏感性和特异性），然后将这些值与先前推荐的肌肉减少症诊断标准进行了比较。
对 6 项以行动受限风险增加为特征的随机对照试验进行回顾性分析。
国家和国际老年临床研究中心。
共纳入 925 名行动受限的老年人（≥55 岁；58%为女性）进行分析。
使用 5 种候选指标评估低肌肉力量和瘦体重的患病率，这些指标可用于区分行动缓慢。对敏感性和特异性的分析用于比较肌肉无力标准与肌肉减少症的已发表诊断标准。
优势比（ORs）支持最大握力（男性和女性的握力最大分别为<35.5 和 20.0）是男女行动缓慢最具鉴别力的指标（OR 分别为 3.66 和 3.53）。更多的男性（58%）而不是女性（30%）低于男女专用的最大握力切点。当将先前推荐的肌肉减少症成分定义应用于我们的人群时，我们发现符合这些标准的个体更少（范围为 6%-32%）。
与以前的建议相比，更多的人低于 SDOC 握力最大切点。与老年人一起工作的临床医生和研究人员可能会考虑将这些阈值作为一种包容性的手段，以确定低风险生活方式促生成和功能促进治疗的候选者。美国老年学会杂志 68：1445-1453，2020。
